LGR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LGR5_HUMAN
• UniProt AC: O75473
• Protein Name: Leucine-rich repeat-containing G-protein coupled receptor 5
• Gene Name: LGR5
• Organism: Homo sapiens (Human).
• Sequence Length: 907
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may
• Protein Description: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development..
• Protein Sequence: MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSSVAFVPCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTSRLGVLL -----CCHHHHHHHH	17.91	24043423
4	Phosphorylation	----MDTSRLGVLLS ----CCHHHHHHHHH	22.65	24043423
11	Phosphorylation	SRLGVLLSLPVLLQL HHHHHHHHHHHHHHH	26.85	24043423
20	Phosphorylation	PVLLQLATGGSSPRS HHHHHHHHCCCCCCC	51.14	30576142
27	Phosphorylation	TGGSSPRSGVLLRGC HCCCCCCCCEEECCC	36.32	22210691
63	N-linked_Glycosylation	GLSELPSNLSVFTSY CCCCCCCCHHHHHHH	34.10	UniProtKB CARBOHYD
77	N-linked_Glycosylation	YLDLSMNNISQLLPN HHCCCCCCHHHHCCC	27.01	UniProtKB CARBOHYD
88	Phosphorylation	LLPNPLPSLRFLEEL HCCCCCCHHHHHHHH	39.60	24719451
114	Phosphorylation	KGAFTGLYSLKVLML CCHHHHHHHHEEEEC	17.19	-
115	Phosphorylation	GAFTGLYSLKVLMLQ CHHHHHHHHEEEECC	27.10	24719451
175	Phosphorylation	WLDDNALTEIPVQAF ECCCCCCCCCCHHHH	29.47	28387310
208	N-linked_Glycosylation	IPDYAFGNLSSLVVL CCCHHCCCHHHEEEE	30.23	23756651
387	Phosphorylation	DLRHNEIYEIKVDTF CCCCCEEEEEECHHH	12.86	27251275
423	Phosphorylation	NAFSTLPSLIKLDLS CHHHCCCHHHHCCCC	45.93	24719451
500	N-linked_Glycosylation	NQWNKGDNSSMDDLH CCCCCCCCCCHHHHH	44.65	UniProtKB CARBOHYD
581	Phosphorylation	CNALVTSTVFRSPLY HCHHHHCHHCCCCCC	17.82	24719451
590	Phosphorylation	FRSPLYISPIKLLIG CCCCCCCCHHHHHHH	13.66	21060948
721	Phosphorylation	PLPFGEPSTMGYMVA ECCCCCCCHHHHHHH	27.07	-
722	Phosphorylation	LPFGEPSTMGYMVAL CCCCCCCHHHHHHHH	25.90	-
792	N-linked_Glycosylation	LSFSSLINLTFISPE HCHHHHCCCCCCCHH	38.02	UniProtKB CARBOHYD
833	Phosphorylation	HFKEDLVSLRKQTYV CHHHHHHHHHHCEEE	29.74	24719451
838	Phosphorylation	LVSLRKQTYVWTRSK HHHHHHCEEEEECCC	24.07	23663014
839	Phosphorylation	VSLRKQTYVWTRSKH HHHHHCEEEEECCCC	7.47	23663014
842	Phosphorylation	RKQTYVWTRSKHPSL HHCEEEEECCCCCCC	18.28	23663014
844	Phosphorylation	QTYVWTRSKHPSLMS CEEEEECCCCCCCCC	28.13	23663014
848	Phosphorylation	WTRSKHPSLMSINSD EECCCCCCCCCCCCH	36.10	27732954
851	Phosphorylation	SKHPSLMSINSDDVE CCCCCCCCCCCHHHH	24.74	27732954
854	Phosphorylation	PSLMSINSDDVEKQS CCCCCCCCHHHHHCC	33.25	27732954
861	Phosphorylation	SDDVEKQSCDSTQAL CHHHHHCCCCCCCEE	30.84	-
864	Phosphorylation	VEKQSCDSTQALVTF HHHCCCCCCCEEEEE	27.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:31867777
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:31867777

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LGR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LGR5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZNRF3_MOUSE	Znrf3	physical	24225776
ZNRF3_HUMAN	ZNRF3	physical	26123262
RSPO2_MOUSE	Rspo2	physical	26123262

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.