dbPTM

LFG4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LFG4_HUMAN
UniProt AC	Q9HC24
Protein Name	Protein lifeguard 4
Gene Name	TMBIM4
Organism	Homo sapiens (Human).
Sequence Length	238
Subcellular Localization	Golgi apparatus membrane Multi-pass membrane protein .
Protein Description	Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release..
Protein Sequence	MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
19	Phosphorylation	SIEDDFNYGSSVASA CCCCCCCCCCCHHHH	20.55	-
80	Phosphorylation	ILLFALGSLGLIFAL HHHHHHHHHHHHHHH	21.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LFG4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LFG4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LFG4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S27A4_HUMAN	SLC27A4	physical	17353931
RPN2_HUMAN	RPN2	physical	17353931
CCD47_HUMAN	CCDC47	physical	17353931
OST48_HUMAN	DDOST	physical	17353931
PPIB_HUMAN	PPIB	physical	17353931
MTX1_HUMAN	MTX1	physical	17353931
KPRA_HUMAN	PRPSAP1	physical	17353931
DFFA_HUMAN	DFFA	physical	17353931
COX41_HUMAN	COX4I1	physical	17353931

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LFG4_HUMAN

Related Literatures of Post-Translational Modification