LAIR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAIR1_HUMAN
• UniProt AC: Q6GTX8
• Protein Name: Leukocyte-associated immunoglobulin-like receptor 1
• Gene Name: LAIR1
• Organism: Homo sapiens (Human).
• Sequence Length: 287
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells..
• Protein Sequence: MSPHPTALLGLVLCLAQTIHTQEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERESRSTYNDTEDVSQASPSESEARFRIDSVSEGNAGPYRCIYYKPPKWSEQSDYLELLVKETSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHLYILIGVSVVFLFCLLLLVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSALAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPHPTALL ------CCCCHHHHH	31.73	24043423
6	Phosphorylation	--MSPHPTALLGLVL --CCCCHHHHHHHHH	27.23	24043423
18	Phosphorylation	LVLCLAQTIHTQEED HHHHHHHHHHCCCCC	14.76	24043423
21	Phosphorylation	CLAQTIHTQEEDLPR HHHHHHHCCCCCCCC	33.55	24043423
32	Phosphorylation	DLPRPSISAEPGTVI CCCCCCCCCCCCCEE	30.80	22210691
67	Phosphorylation	LERESRSTYNDTEDV EEECCCCCCCCCCCH	25.82	30576142
68	Phosphorylation	ERESRSTYNDTEDVS EECCCCCCCCCCCHH	16.58	30576142
69	N-linked_Glycosylation	RESRSTYNDTEDVSQ ECCCCCCCCCCCHHH	50.22	19349973
69	N-linked_Glycosylation	RESRSTYNDTEDVSQ ECCCCCCCCCCCHHH	50.22	19349973
80	Phosphorylation	DVSQASPSESEARFR CHHHCCCCHHHHCEE	51.78	30576142
141	O-linked_Glycosylation	PGSSAGPTQRPSDNS CCCCCCCCCCCCCCC	35.97	OGP
200	Ubiquitination	KQGPPRSKDEEQKPQ HCCCCCCCCCCCCCC	71.13	-
205	Ubiquitination	RSKDEEQKPQQRPDL CCCCCCCCCCCCCCH	48.34	-
245	Phosphorylation	TSALAAGSSQEVTYA HHHHHCCCCCEEEHH	24.91	27080861
246	Phosphorylation	SALAAGSSQEVTYAQ HHHHCCCCCEEEHHH	29.46	27080861
250	Phosphorylation	AGSSQEVTYAQLDHW CCCCCEEEHHHHHHH	16.64	-
251	Phosphorylation	GSSQEVTYAQLDHWA CCCCEEEHHHHHHHH	9.49	22817900
260	Phosphorylation	QLDHWALTQRTARAV HHHHHHHHHHHHHCC	14.30	26074081
263	Phosphorylation	HWALTQRTARAVSPQ HHHHHHHHHHCCCCC	15.63	26074081
268	Phosphorylation	QRTARAVSPQSTKPM HHHHHCCCCCCCCCH	19.08	22115753
271	Phosphorylation	ARAVSPQSTKPMAES HHCCCCCCCCCHHHH	41.61	28464451
272	Phosphorylation	RAVSPQSTKPMAESI HCCCCCCCCCHHHHH	33.64	28464451
273	Ubiquitination	AVSPQSTKPMAESIT CCCCCCCCCHHHHHH	37.73	-
278	Phosphorylation	STKPMAESITYAAVA CCCCHHHHHHHHHHH	15.64	28796482
280	Phosphorylation	KPMAESITYAAVARH CCHHHHHHHHHHHCC	19.18	25072903
281	Phosphorylation	PMAESITYAAVARH- CHHHHHHHHHHHCC-	7.29	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAIR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAIR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAIR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN11_HUMAN	PTPN11	physical	10903717
PTN6_HUMAN	PTPN6	physical	10903717
PTN6_HUMAN	PTPN6	physical	9285412
PTN11_HUMAN	PTPN11	physical	9285412
PTN6_HUMAN	PTPN6	physical	10764762
A4_HUMAN	APP	physical	21832049
LAIR1_HUMAN	LAIR1	physical	21982860
PTN6_HUMAN	PTPN6	physical	15703304

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69, AND MASS SPECTROMETRY.
PubMed: 19349973

Phosphorylation

"Identification and characterization of leukocyte-associated Ig-likereceptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 inhematopoietic cells.";
Xu M.-J., Zhao R., Zhao Z.J.;
J. Biol. Chem. 275:17440-17446(2000).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), FUNCTION,PHOSPHORYLATION AT TYR-251 AND TYR-281, MUTAGENESIS OF TYR-251 ANDTYR-281, AND INTERACTION WITH PTPN6.
PubMed: 10764762