KU70_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KU70_ARATH
• UniProt AC: Q9FQ08
• Protein Name: ATP-dependent DNA helicase 2 subunit KU70
• Gene Name: KU70
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 621
• Subcellular Localization: Nucleus . Cytoplasm . Predominantly in the nucleus.
• Protein Description: Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU80, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand..
• Protein Sequence: MELDPDDVFRDEDEDPENDFFQEKEASKEFVVYLIDASPKMFCSTCPSEEEDKQESHFHIAVSCIAQSLKAHIINRSNDEIAICFFNTREKKNLQDLNGVYVFNVPERDSIDRPTARLIKEFDLIEESFDKEIGSQTGIVSDSRENSLYSALWVAQALLRKGSLKTADKRMFLFTNEDDPFGSMRISVKEDMTRTTLQRAKDAQDLGISIELLPLSQPDKQFNITLFYKDLIGLNSDELTEFMPSVGQKLEDMKDQLKKRVLAKRIAKRITFVICDGLSIELNGYALLRPAIPGSITWLDSTTNLPVKVERSYICTDTGAIMQDPIQRIQPYKNQNIMFTVEELSQVKRISTGHLRLLGFKPLSCLKDYHNLKPSTFLYPSDKEVIGSTRAFIALHRSMIQLERFAVAFYGGTTPPRLVALVAQDEIESDGGQVEPPGINMIYLPYANDIRDIDELHSKPGVAAPRASDDQLKKASALMRRLELKDFSVCQFANPALQRHYAILQAIALDENELRETRDETLPDEEGMNRPAVVKAIEQFKQSIYGDDPDEESDSGAKEKSKKRKAGDADDGKYDYIELAKTGKLKDLTVVELKTYLTANNLLVSGKKEVLINRILTHIGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	Phosphorylation	VSDSRENSLYSALWV CCCCCCCHHHHHHHH	24.75	23328941
150	Phosphorylation	SRENSLYSALWVAQA CCCCHHHHHHHHHHH	23.37	23328941
543	Phosphorylation	AIEQFKQSIYGDDPD HHHHHHHHHHCCCCC	20.54	19376835
545	Phosphorylation	EQFKQSIYGDDPDEE HHHHHHHHCCCCCCC	21.54	23776212
553	Phosphorylation	GDDPDEESDSGAKEK CCCCCCCCCCCHHHH	34.72	30291188
555	Phosphorylation	DPDEESDSGAKEKSK CCCCCCCCCHHHHHH	50.35	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KU70_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KU70_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KU70_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KU80_ARATH	KU80	physical	18212040
OFP1_ARATH	OFP1	physical	20844935
TRP1_ARATH	TRP1	physical	15589838
KU80_ARATH	KU80	physical	15589838

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.