KU80_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KU80_ARATH
• UniProt AC: Q9FQ09
• Protein Name: ATP-dependent DNA helicase 2 subunit KU80
• Gene Name: KU80
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 680
• Subcellular Localization: Nucleus . Cytoplasm . Predominantly in the nucleus.
• Protein Description: Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU70, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Binds to and recombines double-stranded T-DNA molecules..
• Protein Sequence: MARNREGLVLVLDVGPAMRSVLPDVEKACSMLLQKKLIYNKYDEVGIVVFGTEETGNELAREIGGYENVTVLRNIRVVDELAAEHVKQLPRGTVAGDFLDALIVGMDMLIKMYGNAHKGKKRMCLITNAACPTKDPFEGTKDDQVSTIAMKMAAEGIKMESIVMRSNLSGDAHERVIEENDHLLTLFSSNAIAKTVNVDSPLSLLGSLKTRRVAPVTLFRGDLEINPTMKIKVWVYKKVAEERLPTLKMYSDKAPPTDKFAKHEVKVDYDYKVTAESTEVIAPEERIKGFRYGPQVIPISPDQIETLKFKTDKGMKLLGFTEASNILRHYYMKDVNIVVPDPSKEKSVLAVSAIAREMKETNKVAIVRCVWRNGQGNVVVGVLTPNVSERDDTPDSFYFNVLPFAEDVREFPFPSFNKLPSSWKPDEQQQAVADNLVKMLDLAPSAEEEVLKPDLTPNPVLQRFYEYLELKSKSTDATLPPMDGTFKRLMEQDPELSSNNKSIMDTFRGSFEVKENPKLKKASKRLLRDKPSGSDDEDNRMITYDAKENKIDIVGDANPIQDFEAMISRRDKTDWTEKAITQMKNLIMKLVENCTDEGDKALECVLALRKGCVLEQEPKQFNEFLNHLFKLCQERNLSHLLEHFMSKKITLIPKSEAADSDIVDENAGDFIVKQESMLES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
465	Phosphorylation	NPVLQRFYEYLELKS CHHHHHHHHHHHHHC	13.07	24243849
467	Phosphorylation	VLQRFYEYLELKSKS HHHHHHHHHHHHCCC	8.29	24243849
532	Phosphorylation	RLLRDKPSGSDDEDN HHHCCCCCCCCCCCC	57.58	19880383
534	Phosphorylation	LRDKPSGSDDEDNRM HCCCCCCCCCCCCCE	46.34	27531888

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KU80_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KU80_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KU80_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KU70_ARATH	KU70	physical	12148535

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.