KTNA1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KTNA1_CAEEL
• UniProt AC: P34808
• Protein Name: Meiotic spindle formation protein mei-1 {ECO:0000255|HAMAP-Rule:MF_03023}
• Gene Name: mei-1 {ECO:0000255|HAMAP-Rule:MF_03023}
• Organism: Caenorhabditis elegans.
• Sequence Length: 472
• Subcellular Localization: Cytoplasm, cytoskeleton, spindle pole . Chromosome . Cytoplasm . Localizes to the spindle poles and condensed chromatin during female meiosis (PubMed:10809666, PubMed:12781129, PubMed:8027178, PubMed:16338136). This localization requires mei-2 (PubMe
• Protein Description: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. [PubMed: 28783150 Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles]
• Protein Sequence: MNGDVQSVIRGYLERAQVAKTMSDAGRWNEAGDLLRQLMTDVKSCKISASNRDEHDARNTFLRALEANLKLVQQNVRDEDDLHEAMTRQSGSPEPPADPDVWSKPSPPLPSSSKFGATKKGVGAAGPRPREISKSTSSMSTNPADVKPANPTQGILPQNSAGDSFDASAYDAYIVQAVRGTMATNTENTMSLDDIIGMHDVKQVLHEAVTLPLLVPEFFQGLRSPWKAMVLAGPPGTGKTLIARAIASESSSTFFTVSSTDLSSKWRGDSEKIVRLLFELARFYAPSIIFIDEIDTLGGQRGNSGEHEASRRVKSEFLVQMDGSQNKFDSRRVFVLAATNIPWELDEALRRRFEKRIFIPLPDIDARKKLIEKSMEGTPKSDEINYDDLAARTEGFSGADVVSLCRTAAINVLRRYDTKSLRGGELTAAMESLKAELVRNIDFEAALQAVSPSAGPDTMLKCKEWCDSFGAM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	Phosphorylation	AMTRQSGSPEPPADP HHHHCCCCCCCCCCC		28783150

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
92	S	Phosphorylation	Kinase	MBK-2	Q9XTF3	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	mel-26	Q94420	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KTNA1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KTNA1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL4_CAEEL	rpl-4	physical	14704431
SRD7_CAEEL	srd-7	physical	14704431
KTNA1_CAEEL	mei-1	physical	14704431
GARS_CAEEL	gars-1	physical	14704431
RL18_CAEEL	rpl-18	physical	14704431
RL17_CAEEL	rpl-17	physical	14704431
MEL26_CAEEL	mel-26	physical	14704431
MEL26_CAEEL	mel-26	physical	13679921
MEL26_CAEEL	mel-26	physical	13679922
MEI2_CAEEL	mei-2	physical	18692475
KTNA1_CAEEL	mei-1	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.