KTBL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KTBL1_HUMAN
• UniProt AC: Q9H079
• Protein Name: KATNB1-like protein 1
• Gene Name: KATNBL1 {ECO:0000303|PubMed:26929214}
• Organism: Homo sapiens (Human).
• Sequence Length: 304
• Subcellular Localization: Nucleus . Cytoplasm, cytoskeleton, spindle pole . Localizes to the spindle poles only during mitosis. Sequestered to the nucleus during interphase.
• Protein Description: Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro..
• Protein Sequence: MASETHNVKKRNFCNKIEDHFIDLPRKKISNFTNKNMKEVKKSPKQLAAYINRTVGQTVKSPDKLRKVIYRRKKVHHPFPNPCYRKKQSPGSGGCDMANKENELACAGHLPEKLHHDSRTYLVNSSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNMRLNVALTFWRKRSISELVAYLLRIEDLGVVVDCLPVLTNCLQEEKQYISLGCCVDLLPLVKSLLKSKFEEYVIVGLNWLQAVIKRWWSELSSKTEIINDGNIQILKQQLSGLWEQENHLTLVPGYTGNIAKDVDAYLLQLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	NMKEVKKSPKQLAAY CHHHHHCCHHHHHHH		24719451
50	Phosphorylation	SPKQLAAYINRTVGQ CHHHHHHHHHCHHCC		24719451
54	Phosphorylation	LAAYINRTVGQTVKS HHHHHHCHHCCCCCC		23927012
58	Phosphorylation	INRTVGQTVKSPDKL HHCHHCCCCCCHHHH		23927012
61	Phosphorylation	TVGQTVKSPDKLRKV HHCCCCCCHHHHHHH		25159151
89	Phosphorylation	PCYRKKQSPGSGGCD CCCCCCCCCCCCCCC		28985074
92	Phosphorylation	RKKQSPGSGGCDMAN CCCCCCCCCCCCCCC		28102081
128	Phosphorylation	YLVNSSDSGSSQTES EEEECCCCCCCCCCC		27251275
130	Phosphorylation	VNSSDSGSSQTESPS EECCCCCCCCCCCCC		27251275
131	Phosphorylation	NSSDSGSSQTESPSS ECCCCCCCCCCCCCC		27251275
133	Phosphorylation	SDSGSSQTESPSSKY CCCCCCCCCCCCCCC		27251275
135	Phosphorylation	SGSSQTESPSSKYSG CCCCCCCCCCCCCCC		21815630
137	Phosphorylation	SSQTESPSSKYSGFF CCCCCCCCCCCCCCC		25159151
138	Phosphorylation	SQTESPSSKYSGFFS CCCCCCCCCCCCCCC		27251275
225	Phosphorylation	DLLPLVKSLLKSKFE HHHHHHHHHHHHCCC		24719451
229	Phosphorylation	LVKSLLKSKFEEYVI HHHHHHHHCCCCEEE		-
234	Phosphorylation	LKSKFEEYVIVGLNW HHHCCCCEEEEHHHH		-
247	Acetylation	NWLQAVIKRWWSELS HHHHHHHHHHHHHHH		20167786
251	Phosphorylation	AVIKRWWSELSSKTE HHHHHHHHHHHCCEE		29449344
254	Phosphorylation	KRWWSELSSKTEIIN HHHHHHHHCCEEEEE		29449344
255	Phosphorylation	RWWSELSSKTEIIND HHHHHHHCCEEEEEC		29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KTBL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KTBL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KTBL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT7_HUMAN	KAT7	physical	16169070
HAP1_HUMAN	HAP1	physical	16169070
KTBL1_HUMAN	KATNBL1	physical	25416956
KATL1_HUMAN	KATNAL1	physical	25416956
KTNA1_HUMAN	KATNA1	physical	26186194
KTNB1_HUMAN	KATNB1	physical	26186194
KTNA1_HUMAN	KATNA1	physical	28514442
KTNB1_HUMAN	KATNB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.