KIFC3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIFC3_MOUSE
• UniProt AC: O35231
• Protein Name: Kinesin-like protein KIFC3
• Gene Name: Kifc3
• Organism: Mus musculus (Mouse).
• Sequence Length: 824
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane ; Peripheral membrane protein . Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes along zonula adherens only at mature cell-cell cont
• Protein Description: Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance..
• Protein Sequence: MVPSRRTWNLGATPSLRGLWRVGRVQEPKPGMARPAPASPAARPFPHTGQGRLRTGRGKDILPSGEEDSTSRTAARPSLAQCRALSVDWPGPRSPHRLYLTVQVENLKEKLISQAQEVSRLRSELGGTDAEKHRDRLMVENEQLRQELRRCEVELQELRAQPVVPCEGCEHSQESSQLRDKLSQLQLEVAENKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQEEERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQTRNQHLQEQVAMQRQVLKEMEQQLQNSHQLTVQLRAQIAMYEAELERAHGQMLEEMQSLEEDKNRAIEEAFARAQVEMKAVHENLAGVRTNLLTLQPALRTLTNDYNGLKRQVRGFPLLLQEALRSVKAEIGQAIEEVNSNNQELLRKYRRELQLRKKCHNELVRLKGNIRVIARVRPVTKEDGEGPEATNAVTFDPDDDSIIHLLHKGKPVSFELDKVFSPWASQQDVFQEVQALITSCIDGFNVCIFAYGQTGAGKTYTMEGTPENPGINQRALQLLFSEVQEKASDWQYNITVSAAEIYNEVLRDLLGKEPQEKLEIRLCPDGSGQLYVPGLTEFQVQSVDDINKVFEFGYNNRTTEFTNLNEHSSRSHALLIVTVRGVDCSTGLRTTGKLNLVDLAGSERVGKSGAEGNRLREAQHINRSLSALGDVIAALRSRQGHVPFRNSKLTYLLQDSLSGDSKTLMVVQVSPVEKNTSETLYSLRFAERVRSVELGPGSRRTELGSWSSQEHLEWEPACQTPQPTARAHSAPGSGTSSRPGSIRRKLQPSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVPSRRTWNLGATP -CCCCCCCCCCCCCC	20.00	-
17	Phosphorylation	LGATPSLRGLWRVGR CCCCCCHHHCEEECC	42.36	24719451
39	Phosphorylation	MARPAPASPAARPFP CCCCCCCCCCCCCCC	17.64	28066266
64	Phosphorylation	RGKDILPSGEEDSTS CCCCCCCCCCCCCCC	56.22	22817900
86	Phosphorylation	LAQCRALSVDWPGPR HHHHHHEECCCCCCC	19.62	26824392
94	Phosphorylation	VDWPGPRSPHRLYLT CCCCCCCCCCEEEEE	28.35	29899451
353	Succinylation	ARAQVEMKAVHENLA HHHHHHHHHHHHHHH	33.48	23806337
353	Acetylation	ARAQVEMKAVHENLA HHHHHHHHHHHHHHH	33.48	23806337
533	Phosphorylation	GQTGAGKTYTMEGTP CCCCCCCEEECCCCC	24.25	30635358
534	Phosphorylation	QTGAGKTYTMEGTPE CCCCCCEEECCCCCC	13.94	30635358
535	Phosphorylation	TGAGKTYTMEGTPEN CCCCCEEECCCCCCC	17.61	30635358
539	Phosphorylation	KTYTMEGTPENPGIN CEEECCCCCCCCCCC	17.70	30635358
681	Ubiquitination	AGSERVGKSGAEGNR CCCCCCCCCCCCCCH	42.74	-
700	Phosphorylation	QHINRSLSALGDVIA HHHHHHHHHHHHHHH	23.77	29899451
737	Phosphorylation	SLSGDSKTLMVVQVS HCCCCCCEEEEEEEE	24.84	22871156
750	Phosphorylation	VSPVEKNTSETLYSL EEECCCCCCCCHHHH	38.72	22871156
775	Phosphorylation	LGPGSRRTELGSWSS ECCCCCCCCCCCCCC	34.16	24759943
779	Phosphorylation	SRRTELGSWSSQEHL CCCCCCCCCCCCCCC	36.09	25293948
781	Phosphorylation	RTELGSWSSQEHLEW CCCCCCCCCCCCCCC	24.68	25293948
782	Phosphorylation	TELGSWSSQEHLEWE CCCCCCCCCCCCCCC	33.07	25293948
803	Phosphorylation	QPTARAHSAPGSGTS CCCCCCCCCCCCCCC	34.86	25367039
807	Phosphorylation	RAHSAPGSGTSSRPG CCCCCCCCCCCCCCC	37.53	26026062
809	Phosphorylation	HSAPGSGTSSRPGSI CCCCCCCCCCCCCCC	25.81	25367039
810	Phosphorylation	SAPGSGTSSRPGSIR CCCCCCCCCCCCCCC	28.07	25367039
811	Phosphorylation	APGSGTSSRPGSIRR CCCCCCCCCCCCCCH	42.19	25367039
815	Phosphorylation	GTSSRPGSIRRKLQP CCCCCCCCCCHHCCC	18.66	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIFC3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIFC3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIFC3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAU_HUMAN	MAPT	physical	26496610
CE170_HUMAN	CEP170	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.