KI3L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KI3L1_HUMAN
• UniProt AC: P43629
• Protein Name: Killer cell immunoglobulin-like receptor 3DL1
• Gene Name: KIR3DL1
• Organism: Homo sapiens (Human).
• Sequence Length: 444
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis..
• Protein Sequence: MSLMVVSMACVGLFLVQRAGPHMGGQDKPFLSAWPSAVVPRGGHVTLRCHYRHRFNNFMLYKEDRIHIPIFHGRIFQESFNMSPVTTAHAGNYTCRGSHPHSPTGWSAPSNPVVIMVTGNHRKPSLLAHPGPLVKSGERVILQCWSDIMFEHFFLHKEGISKDPSRLVGQIHDGVSKANFSIGPMMLALAGTYRCYGSVTHTPYQLSAPSDPLDIVVTGPYEKPSLSAQPGPKVQAGESVTLSCSSRSSYDMYHLSREGGAHERRLPAVRKVNRTFQADFPLGPATHGGTYRCFGSFRHSPYEWSDPSDPLLVSVTGNPSSSWPSPTEPSSKSGNPRHLHILIGTSVVIILFILLLFFLLHLWCSNKKNAAVMDQEPAGNRTANSEDSDEQDPEEVTYAQLDHCVFTQRKITRPSQRPKTPPTDTILYTELPNAKPRSKVVSCP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	N-linked_Glycosylation	VTTAHAGNYTCRGSH CCEECCCCEEECCCC	29.71	22020283
102	Phosphorylation	CRGSHPHSPTGWSAP ECCCCCCCCCCCCCC	28.71	23532336
118	Phosphorylation	NPVVIMVTGNHRKPS CCEEEEEECCCCCCH	18.19	23532336
179	N-linked_Glycosylation	HDGVSKANFSIGPMM CCCCCCCCCCHHHHH	34.63	22020283
223	Sumoylation	VVTGPYEKPSLSAQP EEECCCCCCCCCCCC	33.78	-
225	Phosphorylation	TGPYEKPSLSAQPGP ECCCCCCCCCCCCCC	46.13	28302921
227	Phosphorylation	PYEKPSLSAQPGPKV CCCCCCCCCCCCCCC	29.24	28302921
245	Phosphorylation	ESVTLSCSSRSSYDM CCEEEEECCCCCEEC	25.96	-
246	Phosphorylation	SVTLSCSSRSSYDMY CEEEEECCCCCEECC	40.27	-
273	N-linked_Glycosylation	LPAVRKVNRTFQADF CHHHHCCCCEEECCC	40.07	22020283
296	Phosphorylation	GTYRCFGSFRHSPYE CCEEEEEECCCCCCC	10.00	11733001
385	Phosphorylation	AGNRTANSEDSDEQD CCCCCCCCCCCCCCC	40.07	17911614
388	Phosphorylation	RTANSEDSDEQDPEE CCCCCCCCCCCCHHH	38.71	17911614
415	Phosphorylation	QRKITRPSQRPKTPP CCCCCCHHHCCCCCC	35.21	17911614
420	Phosphorylation	RPSQRPKTPPTDTIL CHHHCCCCCCCCCEE	36.86	17911614
423	Phosphorylation	QRPKTPPTDTILYTE HCCCCCCCCCEEEEE	47.15	29978859
425	Phosphorylation	PKTPPTDTILYTELP CCCCCCCCEEEEECC	18.50	29978859
428	Phosphorylation	PPTDTILYTELPNAK CCCCCEEEEECCCCC	8.36	29978859
429	Phosphorylation	PTDTILYTELPNAKP CCCCEEEEECCCCCC	27.83	24719451
442	Phosphorylation	KPRSKVVSCP----- CCCCCCCCCC-----	24.53	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
385	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
385	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
388	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
388	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
415	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
415	S	Phosphorylation	Kinase	PRKCB	P05771-2	GPS
415	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
415	S	Phosphorylation	Kinase	PRKCG	P05129	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KI3L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KI3L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KS6B1_HUMAN	RPS6KB1	physical	21988832
KI2L2_HUMAN	KIR2DL2	physical	26186194
F1142_HUMAN	FAM114A2	physical	26186194
KI2L2_HUMAN	KIR2DL2	physical	28514442
F1142_HUMAN	FAM114A2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.