| UniProt ID | KEN_DROME | |
|---|---|---|
| UniProt AC | O77459 | |
| Protein Name | Transcription factor Ken | |
| Gene Name | ken | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 601 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles.. | |
| Protein Sequence | MKEFQRMLMLQYSKHGECILKEIGAAFRGEHPADLTIVCENKVKLHAHKLVLAAASPLIRNLLEDTHLSDCSTTVYFPDVNATYFKFLLDFLYSGQTCITSRDVNYLHDLLLLLQIKSDSWKTTDSAYLSSKCGGLRDRADRRKQQYTSPQNLEPDQTLKYEVDSVDESRNAADFSSAFNSNDNCESAAECERSGGHNNKEEDEDDCTHKDNKSDKDTDEIVNLSNAPPSGTSGSNSNISTSSNHQQQQHHHHHHHNHNNNNNNNNNNSSSSTINPVNLSLDLRTKSENSASRTLGSGSDHSGIDLAVTASESTKRKGLFFDSHKDVMKPLSDGSDINSSPENYVVTPHRKRRPGFHNTQSDNQPFTSYPHSLLEELRLAKSTTSPISGFGSEKNMLAHLEDGALNGDTLTPDRKHLLEAQRNRAQSPEIPMHLGPQFVYQWQSNQNAAMSAMPNLQSRLSSLSHISLNLDHPEGRSGSASGSGANLAGSNTHASSVREYRCEYCGKQFGMSWNLKTHLRVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVRHLSGHHNNLLLTKNLRE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 165 | Phosphorylation | TLKYEVDSVDESRNA CEEEEECCCCCCCCH | 36.32 | 19429919 | |
| 169 | Phosphorylation | EVDSVDESRNAADFS EECCCCCCCCHHHHH | 26.77 | 27626673 | |
| 332 | Phosphorylation | KDVMKPLSDGSDINS CCCCCCCCCCCCCCC | 48.75 | 19429919 | |
| 335 | Phosphorylation | MKPLSDGSDINSSPE CCCCCCCCCCCCCCC | 40.06 | 19429919 | |
| 339 | Phosphorylation | SDGSDINSSPENYVV CCCCCCCCCCCCEEE | 47.83 | 19429919 | |
| 340 | Phosphorylation | DGSDINSSPENYVVT CCCCCCCCCCCEEEC | 31.57 | 19429919 | |
| 344 | Phosphorylation | INSSPENYVVTPHRK CCCCCCCEEECCCCC | 8.47 | 19429919 | |
| 347 | Phosphorylation | SPENYVVTPHRKRRP CCCCEEECCCCCCCC | 11.88 | 19429919 | |
| 382 | Phosphorylation | EELRLAKSTTSPISG HHHHHHHCCCCCCCC | 31.17 | 25749252 | |
| 384 | Phosphorylation | LRLAKSTTSPISGFG HHHHHCCCCCCCCCC | 39.33 | 25749252 | |
| 385 | Phosphorylation | RLAKSTTSPISGFGS HHHHCCCCCCCCCCC | 21.96 | 22668510 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KEN_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KEN_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KEN_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LOLAL_DROME | lolal | physical | 14605208 | |
| LOLAL_DROME | lolal | physical | 22036573 | |
| DECA_DROME | dpp | genetic | 14518006 | |
| CAD_DROME | cad | genetic | 14518006 | |
| TLL_DROME | tll | genetic | 14518006 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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