KCRS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCRS_HUMAN
• UniProt AC: P17540
• Protein Name: Creatine kinase S-type, mitochondrial
• Gene Name: CKMT2
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
• Protein Description: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa..
• Protein Sequence: MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCAEVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MASIFSKLLTGRN --CHHHHHHHHHCCC	22.26	24719451
69	Phosphorylation	NCMAECLTPAIYAKL CHHHHHCHHHHHHHH	23.49	26437602
73	Phosphorylation	ECLTPAIYAKLRNKV HHCHHHHHHHHHCCC	10.37	24641631
85	Phosphorylation	NKVTPNGYTLDQCIQ CCCCCCCCCHHHHHH	15.69	-
142	Phosphorylation	DPRVMKHTTDLDASK CHHHCCCCCCCCHHH	19.25	20833797
143	Phosphorylation	PRVMKHTTDLDASKI HHHCCCCCCCCHHHC	33.99	20833797
148	Phosphorylation	HTTDLDASKITQGQF CCCCCCHHHCCCCCC	25.02	19764811
151	Phosphorylation	DLDASKITQGQFDEH CCCHHHCCCCCCCCE	30.31	20833797
159	Phosphorylation	QGQFDEHYVLSSRVR CCCCCCEEEEECCCC	10.88	20068231
162	Phosphorylation	FDEHYVLSSRVRTGR CCCEEEEECCCCCCC	13.17	20068231
163	Phosphorylation	DEHYVLSSRVRTGRS CCEEEEECCCCCCCC	30.54	20068231
167	Phosphorylation	VLSSRVRTGRSIRGL EEECCCCCCCCCCCC	33.81	21406692
170	Phosphorylation	SRVRTGRSIRGLSLP CCCCCCCCCCCCCCC	20.27	20068231
175	Phosphorylation	GRSIRGLSLPPACTR CCCCCCCCCCCCCCH	41.47	20068231
181	Phosphorylation	LSLPPACTRAERREV CCCCCCCCHHHHHHH	34.71	20068231
207	Phosphorylation	KGDLAGRYYKLSEMT CCHHHHCEEEHHHCC	12.20	19764811
208	Phosphorylation	GDLAGRYYKLSEMTE CHHHHCEEEHHHCCH	12.23	19764811
211	Phosphorylation	AGRYYKLSEMTEQDQ HHCEEEHHHCCHHHH	22.59	19764811
214	Phosphorylation	YYKLSEMTEQDQQRL EEEHHHCCHHHHHHH	26.83	20833797
233	Phosphorylation	FLFDKPVSPLLTCAG CCCCCCCCHHHHHHH	20.54	26437602
255	Phosphorylation	ARGIWHNYDKTFLIW CCCCEECCCCCEEEE	13.11	26437602
281	Acetylation	MEKGGNMKRVFERFC EECCCHHHHHHHHHH	49.78	7709605
313	Phosphorylation	MWNERLGYILTCPSN HHCCCCEEEEECCCC	9.43	28152594
316	Phosphorylation	ERLGYILTCPSNLGT CCCEEEEECCCCCCC	16.89	27251275
319	Phosphorylation	GYILTCPSNLGTGLR EEEEECCCCCCCCCC	47.00	27499020
323	Phosphorylation	TCPSNLGTGLRAGVH ECCCCCCCCCCCEEE	35.89	27251275
343	Phosphorylation	LSKDPRFSKILENLR CCCCHHHHHHHHHHH	21.77	19764811
350	Methylation	SKILENLRLQKRGTG HHHHHHHHHHHCCCC	46.80	-
356	Phosphorylation	LRLQKRGTGGVDTAA HHHHHCCCCCCCHHH	34.49	20833797
361	Phosphorylation	RGTGGVDTAAVADVY CCCCCCCHHHEEEEE	17.70	19764811
368	Phosphorylation	TAAVADVYDISNIDR HHHEEEEEECCCCCC	14.22	19764811
371	Phosphorylation	VADVYDISNIDRIGR EEEEEECCCCCCCCC	25.49	24641631
393	Phosphorylation	IVIDGVNYLVDCEKK EEECCCCEEEEHHHH	13.00	-
419	Acetylation	PLPQFGKK------- CCCCCCCC-------	66.98	30587683

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCRS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCRS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCRS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OLFL3_HUMAN	OLFML3	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
ELN_HUMAN	ELN	physical	21988832
TMED9_HUMAN	TMED9	physical	21988832
CH10_HUMAN	HSPE1	physical	26344197
KCRM_HUMAN	CKM	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00148: Creatine