KCNA5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNA5_RAT
• UniProt AC: P19024
• Protein Name: Potassium voltage-gated channel subfamily A member 5
• Gene Name: Kcna5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 602
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. [PubMed: 2361015]
• Protein Sequence: MEISLVPLENGSAMTLRGGGEAGASCVQTPRGECGCPPTSGLNNQSKETLLRGRTTLEDANQGGRPLPPMAQELPQPRRLSAEDEEGEGDPGLGTVEEDQAPQDAGSLHHQRVLINISGLRFETQLGTLAQFPNTLLGDPAKRLHYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGINGSVSGALSSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNHGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGNQRRESGLDTGGQRKVSCSKASFCKTGGSLESSDSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRETDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	LPQPRRLSAEDEEGE CCCCCCCCCCCCCCC	28.00	-
337	S-palmitoylation	LLVRFFACPSKAEFS HHHHHHHCCCHHHHH	3.10	-
535	Phosphorylation	QGNQRRESGLDTGGQ HHHHHHHCCCCCCCC	42.73	25403869
546	Phosphorylation	TGGQRKVSCSKASFC CCCCEEEEECCCCCC	18.73	-
569	Phosphorylation	SDSIRRGSCPLEKCH CCCCCCCCCCHHHCC	15.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
81	S	Phosphorylation	Kinase	CK2	-	Uniprot
81	S	Phosphorylation	Kinase	PKA	-	Uniprot
535	S	Phosphorylation	Kinase	PKA	-	Uniprot
546	S	Phosphorylation	Kinase	PKA	-	Uniprot
569	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNA5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNA5_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCTN2_RAT	Dctn2	physical	16051887
DC1I1_RAT	Dync1i1	physical	16051887
DLG1_RAT	Dlg1	physical	15277200
CAV3_RAT	Cav3	physical	15277200
KPCZ_RAT	Prkcz	physical	17699685
SQSTM_RAT	Sqstm1	physical	17699685

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.