JTB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JTB_HUMAN
• UniProt AC: O76095
• Protein Name: Protein JTB
• Gene Name: JTB
• Organism: Homo sapiens (Human).
• Sequence Length: 146
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Mitochondrion. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Detected at the centrosome and along spindle fibers during prophase and m
• Protein Description: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity)..
• Protein Sequence: MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Ubiquitination	EAPVQEEKLSASTSN CCCCCHHHHCCCCCC	47.17	29967540
43	O-linked_Glycosylation	EEKLSASTSNLPCWL HHHHCCCCCCCCEEE	22.73	OGP
69	Ubiquitination	PCSNFRAKTTPECGP CCCCCCCCCCCCCCC	48.99	21963094
71	O-linked_Glycosylation	SNFRAKTTPECGPTG CCCCCCCCCCCCCCC	19.18	OGP
82	Acetylation	GPTGYVEKITCSSSK CCCCCEEEEECCCCC	33.02	26051181
82	Ubiquitination	GPTGYVEKITCSSSK CCCCCEEEEECCCCC	33.02	29967540
89	Ubiquitination	KITCSSSKRNEFKSC EEECCCCCCCCHHHH	62.28	27667366
95	Phosphorylation	SKRNEFKSCRSALME CCCCCHHHHHHHHHH	21.78	32142685
98	Phosphorylation	NEFKSCRSALMEQRL CCHHHHHHHHHHHHH	30.04	32142685
138	Ubiquitination	LDRKALEKVRKQIES HCHHHHHHHHHHHHC	48.46	-
141	Ubiquitination	KALEKVRKQIESI-- HHHHHHHHHHHCC--	59.63	-
145	Phosphorylation	KVRKQIESI------ HHHHHHHCC------	34.92	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JTB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JTB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JTB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZXDC_HUMAN	ZXDC	physical	21900206
A4_HUMAN	APP	physical	21832049
ELOC_HUMAN	TCEB1	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.