IRS4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IRS4_SCHPO
• UniProt AC: O14066
• Protein Name: Increased rDNA silencing protein 4 homolog
• Gene Name: SPAC1687.09
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1379
• Protein Description: Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity)..
• Protein Sequence: MDAIHPVSLRNSKRHPLLHSERNLSRRAVSPSISRSFFQHSNGSFPLFQNHRKSLPSAIYKSVDPYVDANPLDPLAAAKASFADFPEQDDSQSSTSPLSSKYHTKKNKQIFVEDSRRGGAASNAAAIAAKKSGYYERTSTRKRSLTVPTPRTSFPHHPRSRRFSLKNAAIATSYHKFKPLSSNSLSSSGMHFSASKQAFNSPLLQTFSPSPSVSPFSNPAVEKLKTSASKQAAEAQSLREFDFFTPTPEPSDKNLEKLKNGASKQASESQSLKNMESLSLARSSPILTSEKLKNGASKQAIESPPFRASEPLPSSNIIPNPAMERLKNGASKLAIESQPFKSAEPLSSAIPLPNPMSEKMRNGASKQAIMAQSSKINPLPPLTASISDPSFEKLKNTASKQAIESQSLMNSGPELLEPSISDPMLEKMKTDAGKQTVESLSLKSSDATIPKPSVSDLGVEKLKNDASKCAVESQSLMINDPSVSSTSFYNPNMEKLKNGAIKQAIEHQALNAAILNKTQLPYFHQSSSELPISASKRAALSQQTESASKSSSNISEMCDSHPPSNFSISASQQASKDRFSEATSSIDLDLSPGRSLSLASSKLSVKEAGARVYNRSVATPVMTPSNPFEISKSASQLASIAQVPVSEPAKTSEVNLKKSLSLASSKLSFQEAGTSLKEKTANVQHSPEVLNDRSLASLSASRHADAISSKSKQHTEIAQPAFNTTGTVLMKTKSNLSDSALSTPQHSDSVLFDITSKAARLASTCAKTDLHRKPRRKHKSFTLENYFGHNAEDESPQSDEVESQTPPSGYSENDIGGTDIYPFALQGAALAAAKDFSRREASLSDSQSAASMDMLPMKKKLSHSSASSTRSIKSLLTNANQKHIHSSINETDDIPTMAAHIVATGQKNKEKAPSFSNDQALDHLLGSAHKRIPSNKTEWSSSSLHIPSHNSFSDIHHRKIAAHAAAITAASEKLTPSIEETSYSSSKAHDASLSAATLVANKDKLIHAPTPQVLAPVLPKVSLPHRHSVSLGQIRGESEVEGDVFYDAPSDKEDLGSSNAPLDVPHGANRSSMDEVNGSKYDYSDGILDGSGQYTDSDMSDDENSLKDSQSSVLSFSAVPTKVLKFKLRDVLGSEYSPSPQLLASSSDVSGSSSAVRAAMKADKIFPAVHENPPPLKTKQSIAKPSPHTLRVPQKKHKHFYHRDDGKYKSGTNLRKSETVDLPQFFIDENRRKLYEGLWAANKGYLLSKSEYSKPNDLICNIVVRELWSRSGAPTSVLAKIYDLVDRHHTGVLGRDEFIVGMFLIDQYLKGRKLPLKVPDSVWLSSKRMGDMLWRLEKLQKKTDNKKPFFKKKKKKRKHLKKFFDFNTTAKVNEGAMTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	NLSRRAVSPSISRSF CHHHHCCCHHHHHHH	16.37	29996109
32	Phosphorylation	SRRAVSPSISRSFFQ HHHCCCHHHHHHHHH	26.20	29996109
44	Phosphorylation	FFQHSNGSFPLFQNH HHHCCCCCCCCHHCC	28.13	25720772
146	Phosphorylation	STRKRSLTVPTPRTS CCCCCCCCCCCCCCC	26.19	29996109
247	Phosphorylation	EFDFFTPTPEPSDKN HCCCCCCCCCCCCCC	36.91	24763107
283	Phosphorylation	ESLSLARSSPILTSE HHHHHHHHCCCCCHH	34.55	24763107
284	Phosphorylation	SLSLARSSPILTSEK HHHHHHHCCCCCHHH	15.48	21712547
387	Phosphorylation	PPLTASISDPSFEKL CCCCCCCCCCCHHHH	40.76	25720772
528	Phosphorylation	PYFHQSSSELPISAS CCCCCCCCCCCCCHH	48.69	24763107
550	Phosphorylation	QTESASKSSSNISEM HHHHHHHCCCCHHHH	36.18	27738172
591	Phosphorylation	SSIDLDLSPGRSLSL CCCCCCCCCCCCHHH	25.60	25720772
595	Phosphorylation	LDLSPGRSLSLASSK CCCCCCCCHHHHHCC	28.38	25720772
597	Phosphorylation	LSPGRSLSLASSKLS CCCCCCHHHHHCCCC	24.12	25720772
600	Phosphorylation	GRSLSLASSKLSVKE CCCHHHHHCCCCHHH	33.04	25720772
601	Phosphorylation	RSLSLASSKLSVKEA CCHHHHHCCCCHHHH	31.82	25720772
604	Phosphorylation	SLASSKLSVKEAGAR HHHHCCCCHHHHCCE	34.57	25720772
659	Phosphorylation	SEVNLKKSLSLASSK CCCCHHHHHHHHHHC	22.92	25720772
661	Phosphorylation	VNLKKSLSLASSKLS CCHHHHHHHHHHCCC	29.04	25720772
664	Phosphorylation	KKSLSLASSKLSFQE HHHHHHHHHCCCHHH	33.04	25720772
665	Phosphorylation	KSLSLASSKLSFQEA HHHHHHHHCCCHHHH	31.82	25720772
668	Phosphorylation	SLASSKLSFQEAGTS HHHHHCCCHHHHCCC	28.72	25720772
680	Phosphorylation	GTSLKEKTANVQHSP CCCHHHHHCCCCCCH	25.26	29996109
686	Phosphorylation	KTANVQHSPEVLNDR HHCCCCCCHHHHCCH	12.98	29996109
732	Phosphorylation	TGTVLMKTKSNLSDS CCCEEEEECCCCCCC	26.24	24763107
734	Phosphorylation	TVLMKTKSNLSDSAL CEEEEECCCCCCCCC	48.51	24763107
737	Phosphorylation	MKTKSNLSDSALSTP EEECCCCCCCCCCCC	33.50	29996109
739	Phosphorylation	TKSNLSDSALSTPQH ECCCCCCCCCCCCCC	27.94	21712547
742	Phosphorylation	NLSDSALSTPQHSDS CCCCCCCCCCCCCCC	37.45	25720772
868	Phosphorylation	LSHSSASSTRSIKSL CCCCCCCCHHHHHHH	27.79	21712547
871	Phosphorylation	SSASSTRSIKSLLTN CCCCCHHHHHHHHHH	34.16	21712547
874	Phosphorylation	SSTRSIKSLLTNANQ CCHHHHHHHHHHCCH	27.26	24763107
914	Phosphorylation	KNKEKAPSFSNDQAL CCHHCCCCCCHHHHH	46.28	24763107
916	Phosphorylation	KEKAPSFSNDQALDH HHCCCCCCHHHHHHH	43.78	21712547
927	Phosphorylation	ALDHLLGSAHKRIPS HHHHHHHCHHHCCCC	27.46	24763107
977	Phosphorylation	ASEKLTPSIEETSYS HHHHCCCCCHHHCCC	37.08	27738172
1022	Phosphorylation	APVLPKVSLPHRHSV CCCCCCCCCCCCCEE	42.16	29996109
1028	Phosphorylation	VSLPHRHSVSLGQIR CCCCCCCEEECCCCC	17.23	28889911
1030	Phosphorylation	LPHRHSVSLGQIRGE CCCCCEEECCCCCCC	29.78	25720772
1050	Phosphorylation	DVFYDAPSDKEDLGS CEEECCCCCHHHCCC	64.14	29996109
1072	Phosphorylation	PHGANRSSMDEVNGS CCCCCCCCCCCCCCC	27.32	24763107
1109	Phosphorylation	DENSLKDSQSSVLSF CCCCCCCCHHHHHHH	30.30	21712547
1111	Phosphorylation	NSLKDSQSSVLSFSA CCCCCCHHHHHHHCC	26.77	21712547
1112	Phosphorylation	SLKDSQSSVLSFSAV CCCCCHHHHHHHCCC	21.31	24763107
1115	Phosphorylation	DSQSSVLSFSAVPTK CCHHHHHHHCCCCCC	18.26	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IRS4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IRS4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IRS4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YK98_SCHPO	whi2	genetic	22681890
UPP2_SCHPO	SPAC1399.04c	genetic	22681890
AAT1_SCHPO	aat1	genetic	22681890
YAN8_SCHPO	SPAC3H1.08c	genetic	22681890
YPT71_SCHPO	ypt71	genetic	22681890
YE8A_SCHPO	SPAC9G1.10c	genetic	22681890
ARV1_SCHPO	arv1	genetic	22681890
MAM3_SCHPO	mam3	genetic	22681890
YK18_SCHPO	SPAPB1A10.08	genetic	22681890

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.