UniProt ID | IRF8_MOUSE | |
---|---|---|
UniProt AC | P23611 | |
Protein Name | Interferon regulatory factor 8 | |
Gene Name | Irf8 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 424 | |
Subcellular Localization | Nucleus . Cytoplasm . In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. | |
Protein Description | Plays a role as a transcriptional activator or repressor (By similarity). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. [PubMed: 22992524] | |
Protein Sequence | MCDRNGGRRLRQWLIEQIDSSMYPGLIWENDEKTMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVAPAGCMSEVPEMECGRSEIEELIKEPSVDEYMGMTKRSPSPPEACRSQILPDWWVQQPSAGLPLVTGYAAYDTHHSAFSQMVISFYYGGKLVGQATTTCLEGCRLSLSQPGLPKLYGPDGLEPVCFPTADTIPSERQRQVTRKLFGHLERGVLLHSNRKGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTNQFIRELQQFYATQSRLPDSRVVLCFGEEFPDTVPLRSKLILVQVEQLYARQLVEEAGKSCGAGSLMPALEEPQPDQAFRMFPDICTSHQRPFFRENQQITV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
107 | Phosphorylation | QLDISEPYKVYRIVP HCCCCCCCEEEEECC | 14.72 | 17200120 | |
151 | Phosphorylation | EELIKEPSVDEYMGM HHHHHCCCHHHHCCC | 43.20 | 24704852 | |
162 | Phosphorylation | YMGMTKRSPSPPEAC HCCCCCCCCCCCHHH | 31.14 | 25159016 | |
164 | Phosphorylation | GMTKRSPSPPEACRS CCCCCCCCCCHHHHH | 55.09 | 22942356 | |
211 | Phosphorylation | QMVISFYYGGKLVGQ HHHHHHHCCCEECCE | 19.86 | 22817900 | |
280 | Phosphorylation | ERGVLLHSNRKGVFV HHCEEEECCCCEEEE | 38.00 | 24704852 | |
310 | Sumoylation | VCKGRPNKLERDEVV EECCCCCCCCCCCEE | 55.17 | - | |
333 | Phosphorylation | IRELQQFYATQSRLP HHHHHHHHHHHHCCC | 12.37 | 22817900 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IRF8_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IRF8_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
UBC9_MOUSE | Ube2i | physical | 18955028 | |
SUMO1_MOUSE | Sumo1 | physical | 18955028 | |
IRF4_MOUSE | Irf4 | physical | 10590072 | |
ZBT17_MOUSE | Zbtb17 | physical | 18045875 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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