IRF8_MOUSE - dbPTM
IRF8_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IRF8_MOUSE
UniProt AC P23611
Protein Name Interferon regulatory factor 8
Gene Name Irf8
Organism Mus musculus (Mouse).
Sequence Length 424
Subcellular Localization Nucleus . Cytoplasm . In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction.
Protein Description Plays a role as a transcriptional activator or repressor (By similarity). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. [PubMed: 22992524]
Protein Sequence MCDRNGGRRLRQWLIEQIDSSMYPGLIWENDEKTMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVAPAGCMSEVPEMECGRSEIEELIKEPSVDEYMGMTKRSPSPPEACRSQILPDWWVQQPSAGLPLVTGYAAYDTHHSAFSQMVISFYYGGKLVGQATTTCLEGCRLSLSQPGLPKLYGPDGLEPVCFPTADTIPSERQRQVTRKLFGHLERGVLLHSNRKGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTNQFIRELQQFYATQSRLPDSRVVLCFGEEFPDTVPLRSKLILVQVEQLYARQLVEEAGKSCGAGSLMPALEEPQPDQAFRMFPDICTSHQRPFFRENQQITV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
107PhosphorylationQLDISEPYKVYRIVP
HCCCCCCCEEEEECC
14.7217200120
151PhosphorylationEELIKEPSVDEYMGM
HHHHHCCCHHHHCCC
43.2024704852
162PhosphorylationYMGMTKRSPSPPEAC
HCCCCCCCCCCCHHH
31.1425159016
164PhosphorylationGMTKRSPSPPEACRS
CCCCCCCCCCHHHHH
55.0922942356
211PhosphorylationQMVISFYYGGKLVGQ
HHHHHHHCCCEECCE
19.8622817900
280PhosphorylationERGVLLHSNRKGVFV
HHCEEEECCCCEEEE
38.0024704852
310SumoylationVCKGRPNKLERDEVV
EECCCCCCCCCCCEE
55.17-
333PhosphorylationIRELQQFYATQSRLP
HHHHHHHHHHHHCCC
12.3722817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseCblP22682
PMID:22199232
-KUbiquitinationE3 ubiquitin ligaseTrim21Q62191
PMID:22199232

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IRF8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IRF8_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC9_MOUSEUbe2iphysical
18955028
SUMO1_MOUSESumo1physical
18955028
IRF4_MOUSEIrf4physical
10590072
ZBT17_MOUSEZbtb17physical
18045875

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IRF8_MOUSE

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Related Literatures of Post-Translational Modification

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