IL22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL22_HUMAN
• UniProt AC: Q9GZX6
• Protein Name: Interleukin-22
• Gene Name: IL22
• Organism: Homo sapiens (Human).
• Sequence Length: 179
• Subcellular Localization: Secreted.
• Protein Description: Cytokine that contributes to the inflammatory response in vivo..
• Protein Sequence: MAALQKSVSSFLMGTLATSCLLLLALLVQGGAAAPISSHCRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGEIKAIGELDLLFMSLRNACI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	N-linked_Glycosylation	FQQPYITNRTFMLAK CCCCCCCCCCEEHHH	31.28	15983417
68	N-linked_Glycosylation	KEASLADNNTDVRLI HHHHHCCCCCCEEEH	47.93	UniProtKB CARBOHYD
97	N-linked_Glycosylation	YLMKQVLNFTLEEVL HHHHHHHCCCHHHHH	29.06	15983417
126	Phosphorylation	VPFLARLSNRLSTCH HHHHHHHHHHHCCCE	17.85	22617229
130	Phosphorylation	ARLSNRLSTCHIEGD HHHHHHHCCCEECCC	26.25	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
I22R2_HUMAN	IL22RA2	physical	11390453
I10R2_HUMAN	IL10RB	physical	10875937
I22R1_HUMAN	IL22RA1	physical	10875937

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structure of insect-cell-derived IL-22.";
Xu T., Logsdon N.J., Walter M.R.;
Acta Crystallogr. D 61:942-950(2005).
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 38-179, AND GLYCOSYLATION ATASN-54 AND ASN-97.
PubMed: 15983417