dbPTM

I10R2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	I10R2_HUMAN
UniProt AC	Q08334
Protein Name	Interleukin-10 receptor subunit beta
Gene Name	IL10RB
Organism	Homo sapiens (Human).
Sequence Length	325
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state..
Protein Sequence	MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQVEVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLRNLEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMASVFMVCLALLGCFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDENDVFDKLSVIAEDSESGKQNPGDSCSLGTPPGQGPQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	N-linked_Glycosylation	SPAFAKGNLTFTAQY CCCHHCCCEEEEEEH	34.89	UniProtKB CARBOHYD
68	N-linked_Glycosylation	IFQDKCMNTTLTECD HHHHHHCCCCCCCCC	39.11	UniProtKB CARBOHYD
69	Phosphorylation	FQDKCMNTTLTECDF HHHHHCCCCCCCCCH	9.04	26074081
70	Phosphorylation	QDKCMNTTLTECDFS HHHHCCCCCCCCCHH	27.03	26074081
72	Phosphorylation	KCMNTTLTECDFSSL HHCCCCCCCCCHHHH	32.26	26074081
77	Phosphorylation	TLTECDFSSLSKYGD CCCCCCHHHHHHCCC	19.67	26074081
78	Phosphorylation	LTECDFSSLSKYGDH CCCCCHHHHHHCCCE	36.33	26074081
80	Phosphorylation	ECDFSSLSKYGDHTL CCCHHHHHHCCCEEE	26.27	26074081
82	Phosphorylation	DFSSLSKYGDHTLRV CHHHHHHCCCEEEEE	25.14	26074081
86	Phosphorylation	LSKYGDHTLRVRAEF HHHCCCEEEEEEEEE	22.47	26074081
102	N-linked_Glycosylation	DEHSDWVNITFCPVD CCCCCCEEEEEECCC	24.27	UniProtKB CARBOHYD
140	Phosphorylation	APKIENEYETWTMKN HHHCCCEEEEEEEEC	30.18	27732954
142	Phosphorylation	KIENEYETWTMKNVY HCCCEEEEEEEECCC	25.90	27732954
144	Phosphorylation	ENEYETWTMKNVYNS CCEEEEEEEECCCCC	26.20	27732954
161	N-linked_Glycosylation	YNVQYWKNGTDEKFQ EEEEEEECCCCCCEE	44.44	UniProtKB CARBOHYD
252	Phosphorylation	LWCVYKKTKYAFSPR HHHHHHHHCCCCCCC	25.74	21712546
253	Ubiquitination	WCVYKKTKYAFSPRN HHHHHHHCCCCCCCC	43.38	33845483
257	Phosphorylation	KKTKYAFSPRNSLPQ HHHCCCCCCCCCCCH	18.12	21712546
261	Phosphorylation	YAFSPRNSLPQHLKE CCCCCCCCCCHHHHH	42.58	25056879
296	Phosphorylation	NDVFDKLSVIAEDSE CCHHHHHEEEEECCC	19.74	26657352
302	Phosphorylation	LSVIAEDSESGKQNP HEEEEECCCCCCCCC	25.76	25159151
304	Phosphorylation	VIAEDSESGKQNPGD EEEECCCCCCCCCCC	56.07	21815630
306	Ubiquitination	AEDSESGKQNPGDSC EECCCCCCCCCCCCC	57.06	33845483
312	Phosphorylation	GKQNPGDSCSLGTPP CCCCCCCCCCCCCCC	16.12	29514088
314	Phosphorylation	QNPGDSCSLGTPPGQ CCCCCCCCCCCCCCC	33.51	29514088
317	Phosphorylation	GDSCSLGTPPGQGPQ CCCCCCCCCCCCCCC	31.44	23663014
325	Phosphorylation	PPGQGPQS------- CCCCCCCC-------	45.37	22115753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of I10R2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of I10R2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of I10R2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
I10R1_HUMAN	IL10RA	physical	9312047

Drug and Disease Associations

Kegg Disease
H01227	Inflammatory bowel disease
OMIM Disease
612567	Inflammatory bowel disease 25 (IBD25)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of I10R2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-317, AND MASSSPECTROMETRY.	19413330 [Abstract]