I10R1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: I10R1_HUMAN
• UniProt AC: Q13651
• Protein Name: Interleukin-10 receptor subunit alpha
• Gene Name: IL10RA
• Organism: Homo sapiens (Human).
• Sequence Length: 578
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor for IL10; binds IL10 with a high affinity..
• Protein Sequence: MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	VLLAALLSLRLGSDA HHHHHHHHHHHCCCC	16.58	24719451
50	N-linked_Glycosylation	LHWTPIPNQSESTCY HHCCCCCCCCCCCHH	59.74	UniProtKB CARBOHYD
74	N-linked_Glycosylation	ESWNSISNCSQTLSY HCHHHHCCCCCEECC	27.99	UniProtKB CARBOHYD
109	Phosphorylation	AVDGSRHSNWTVTNT EECCCCCCCCEEEEC	32.71	29449344
110	N-linked_Glycosylation	VDGSRHSNWTVTNTR ECCCCCCCCEEEECE	32.11	UniProtKB CARBOHYD
112	Phosphorylation	GSRHSNWTVTNTRFS CCCCCCCEEEECEEE	23.00	29449344
114	Phosphorylation	RHSNWTVTNTRFSVD CCCCCEEEECEEEEC	24.40	29449344
116	Phosphorylation	SNWTVTNTRFSVDEV CCCEEEECEEEECEE	24.59	29449344
154	N-linked_Glycosylation	RPKMAPANDTYESIF CCCCCCCCCHHHHHH	40.89	UniProtKB CARBOHYD
177	N-linked_Glycosylation	AIRKVPGNFTFTHKK EEEECCCCEEEEECC	27.07	UniProtKB CARBOHYD
183	Acetylation	GNFTFTHKKVKHENF CCEEEEECCCCCCCE	57.09	30589481
189	N-linked_Glycosylation	HKKVKHENFSLLTSG ECCCCCCCEEEEECC	31.37	UniProtKB CARBOHYD
225	Phosphorylation	WSKEECISLTRQYFT CCHHHHHHHHHHHHH	35.03	24719451
268	Phosphorylation	RRRKKLPSVLLFKKP HHHHCCCCEEEECCC	35.51	-
305	Phosphorylation	EEAFLKVSPELKNLD HHHHHHCCHHHCCCC	15.86	24719451
446	Phosphorylation	AAVAFQGYLRQTRCA HHHHHHHHHHHHHCC	6.47	22817900
496	Phosphorylation	PPALAKGYLKQDPLE CCHHHCCCCCCCCCH	15.26	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
446	Y	Phosphorylation	Kinase	TYK2	P29597	PhosphoELM
496	Y	Phosphorylation	Kinase	TYK2	P29597	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of I10R1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of I10R1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAK1_HUMAN	JAK1	physical	12374810
IL10_HUMAN	IL10	physical	8248239
JAK1_HUMAN	JAK1	physical	12133952
FBW1A_HUMAN	BTRC	physical	22087322

Drug and Disease Associations

• Kegg Disease
• H01227: Inflammatory bowel disease
• OMIM Disease
• 613148: Inflammatory bowel disease 28 (IBD28)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.