IL10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL10_HUMAN
• UniProt AC: P22301
• Protein Name: Interleukin-10
• Gene Name: IL10
• Organism: Homo sapiens (Human).
• Sequence Length: 178
• Subcellular Localization: Secreted.
• Protein Description: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells..
• Protein Sequence: MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	N-linked_Glycosylation	HRFLPCENKSKAVEQ HHHCCCCCHHHHHHH	61.69	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
I10R1_HUMAN	IL10RA	physical	11485736
I10R1_HUMAN	IL10RA	physical	7759550
IL10_HUMAN	IL10	physical	8590020
I10R1_HUMAN	IL10RA	physical	11717514
I10R1_HUMAN	IL10RA	physical	10231374
A2MG_HUMAN	A2M	physical	25241761

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.