I13R1_HUMAN - dbPTM
I13R1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID I13R1_HUMAN
UniProt AC P78552
Protein Name Interleukin-13 receptor subunit alpha-1
Gene Name IL13RA1
Organism Homo sapiens (Human).
Sequence Length 427
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity..
Protein Sequence MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37N-linked_GlycosylationETQPPVTNLSVSVEN
CCCCCCCEEEEEEEE		30.47UniProtKB CARBOHYD
61N-linked_GlycosylationPPEGASSNCSLWYFS
CCCCCCCCCEEEEEE		19.53UniProtKB CARBOHYD
82PhosphorylationDKKIAPETRRSIEVP
CCCCCCCCCCCCCCC		30.26-
105N-linked_GlycosylationVGSQCSTNESEKPSI
ECCCCCCCCCCCCEE		34.21UniProtKB CARBOHYD
138N-linked_GlycosylationELQCIWHNLSYMKCS
HHHHHHCCCCCCCCC		18.71UniProtKB CARBOHYD
157N-linked_GlycosylationRNTSPDTNYTLYYWH
CCCCCCCCCEEEEEH		34.86UniProtKB CARBOHYD
182UbiquitinationNIFREGQYFGCSFDL
HHHHCCCEECEEEEE		16.8823000965
185UbiquitinationREGQYFGCSFDLTKV
HCCCEECEEEEEEEE		2.3521890473
235N-linked_GlycosylationPDPPHIKNLSFHNDD
CCCCCCCCEEECCCC		40.07UniProtKB CARBOHYD
242UbiquitinationNLSFHNDDLYVQWEN
CEEECCCCEEEEECC		45.2623000965
245UbiquitinationFHNDDLYVQWENPQN
ECCCCEEEEECCCCC		7.4821890473
265N-linked_GlycosylationLFYEVEVNNSQTETH
EEEEEEECCCCCEEE		29.00UniProtKB CARBOHYD
293N-linked_GlycosylationEFERNVENTSCFMVP
CHHCCCCCCCEEECC		32.77UniProtKB CARBOHYD
329N-linked_GlycosylationEDDKLWSNWSQEMSI
CCCCHHCCHHHHHCC		30.73UniProtKB CARBOHYD
335PhosphorylationSNWSQEMSIGKKRNS
CCHHHHHCCCCCCCC		27.6929888752
341N-linked_GlycosylationMSIGKKRNSTLYITM
HCCCCCCCCHHHHHH		48.50UniProtKB CARBOHYD
366PhosphorylationAIIVLLLYLKRLKII
HHHHHHHHHHHCCEE		15.33-
371UbiquitinationLLYLKRLKIIIFPPI
HHHHHHCCEEECCCC		35.5733845483
383UbiquitinationPPIPDPGKIFKEMFG
CCCCCCCHHHHHHHC		50.8123000965
386UbiquitinationPDPGKIFKEMFGDQN
CCCCHHHHHHHCCCC		52.3121890473
386UbiquitinationPDPGKIFKEMFGDQN
CCCCHHHHHHHCCCC		52.3123000965
400UbiquitinationNDDTLHWKKYDIYEK
CCCCCEEEEHHCEEC		30.6132015554
401UbiquitinationDDTLHWKKYDIYEKQ
CCCCEEEEHHCEECC		42.8633845483
402PhosphorylationDTLHWKKYDIYEKQT
CCCEEEEHHCEECCC		12.1228152594
405PhosphorylationHWKKYDIYEKQTKEE
EEEEHHCEECCCCCC		17.7428152594
407UbiquitinationKKYDIYEKQTKEETD
EEHHCEECCCCCCCC		46.4233845483
409PhosphorylationYDIYEKQTKEETDSV
HHCEECCCCCCCCCE		52.0323312004
410UbiquitinationDIYEKQTKEETDSVV
HCEECCCCCCCCCEE		51.5733845483
413PhosphorylationEKQTKEETDSVVLIE
ECCCCCCCCCEEEEC		34.3730266825
415PhosphorylationQTKEETDSVVLIENL
CCCCCCCCEEEECCH		22.8830266825
423UbiquitinationVVLIENLKKASQ---
EEEECCHHHHCC---		58.8532015554
485Ubiquitination-----------------------------------------------------------------
-----------------------------------------------------------------		23000965
488Ubiquitination--------------------------------------------------------------------
--------------------------------------------------------------------		21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of I13R1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of I13R1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of I13R1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TYK2_HUMANTYK2physical
10409622
TM39B_HUMANTMEM39Bphysical
21988832
M4K3_HUMANMAP4K3physical
28514442
GDS1_HUMANRAP1GDS1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of I13R1_HUMAN

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Related Literatures of Post-Translational Modification

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