HYLS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HYLS1_HUMAN
• UniProt AC: Q96M11
• Protein Name: Hydrolethalus syndrome protein 1
• Gene Name: HYLS1 {ECO:0000312|HGNC:HGNC:26558}
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Subcellular Localization: Cytoplasm . Cell projection, cilium . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole .
• Protein Description: Plays a role in ciliogenesis..
• Protein Sequence: MEELLPDGQIWANMDPEERMLAAATAFTHICAGQGEGDVRREAQSIQYDPYSKASVAPGKRPALPVQLQYPHVESNVPSETVSEASQRLRKPVMKRKVLRRKPDGEVLVTDESIISESESGTENDQDLWDLRQRLMNVQFQEDKESSFDVSQKFNLPHEYQGISQDQLICSLQREGMGSPAYEQDLIVASRPKSFILPKLDQLSRNRGKTDRVARYFEYKRDWDSIRLPGEDHRKELRWGVREQMLCRAEPQSKPQHIYVPNNYLVPTEKKRSALRWGVRCDLANGVIPRKLPFPLSPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	LAAATAFTHICAGQG HHHHHHHHHHHCCCC	14.10	24719451
45	Phosphorylation	DVRREAQSIQYDPYS HHHHHHHCCCCCCCC	20.78	23186163
48	Phosphorylation	REAQSIQYDPYSKAS HHHHCCCCCCCCCCC	19.74	22817900
51	Phosphorylation	QSIQYDPYSKASVAP HCCCCCCCCCCCCCC	21.65	-
53	Ubiquitination	IQYDPYSKASVAPGK CCCCCCCCCCCCCCC	38.55	21906983
75	Phosphorylation	LQYPHVESNVPSETV ECCCCCCCCCCCHHH	41.88	24247654
79	Phosphorylation	HVESNVPSETVSEAS CCCCCCCCHHHHHHH	41.43	24247654
83	Phosphorylation	NVPSETVSEASQRLR CCCCHHHHHHHHHHH	34.56	24247654
144	Ubiquitination	NVQFQEDKESSFDVS HCCCCCCCCCCCCHH	59.76	21906983
147	Phosphorylation	FQEDKESSFDVSQKF CCCCCCCCCCHHHHC	26.93	25850435
153	Ubiquitination	SSFDVSQKFNLPHEY CCCCHHHHCCCCCCC	28.81	-
160	Phosphorylation	KFNLPHEYQGISQDQ HCCCCCCCCCCCHHH	14.70	27642862
179	Phosphorylation	LQREGMGSPAYEQDL HHHCCCCCCHHHCCE	9.47	23401153
182	Phosphorylation	EGMGSPAYEQDLIVA CCCCCCHHHCCEEEE	19.94	30266825
190	Phosphorylation	EQDLIVASRPKSFIL HCCEEEECCCCCCHH	37.92	23927012
194	Phosphorylation	IVASRPKSFILPKLD EEECCCCCCHHHHHH	21.87	24719451
199	Ubiquitination	PKSFILPKLDQLSRN CCCCHHHHHHHHHHC	62.34	-
204	Phosphorylation	LPKLDQLSRNRGKTD HHHHHHHHHCCCCHH	23.13	29083192
259	Phosphorylation	QSKPQHIYVPNNYLV CCCCCEEECCCCEEE	14.02	27642862
264	Phosphorylation	HIYVPNNYLVPTEKK EEECCCCEEECCHHH	18.73	27642862
297	Phosphorylation	RKLPFPLSPS----- CCCCCCCCCC-----	24.28	30266825
299	Phosphorylation	LPFPLSPS------- CCCCCCCC-------	49.86	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HYLS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HYLS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HYLS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERG28_HUMAN	C14orf1	physical	16169070
IDE_HUMAN	IDE	physical	26186194
IDE_HUMAN	IDE	physical	28514442
HAUS8_HUMAN	HAUS8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 236680: Hydrolethalus syndrome 1 (HLS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.