HXA11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXA11_HUMAN
• UniProt AC: P31270
• Protein Name: Homeobox protein Hox-A11
• Gene Name: HOXA11
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKSAEKGPPAATATSAAAAAAATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPESSSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	TPSSRPMTYSYSSNL CCCCCCCCEECCCCC	16.40	30576142
45	Phosphorylation	PSSRPMTYSYSSNLP CCCCCCCEECCCCCC	10.20	30576142
72	Ubiquitination	YAIEPATKWHPRGNL EECCCCCCCCCCCCC	45.68	22817900
72	Ubiquitination	YAIEPATKWHPRGNL EECCCCCCCCCCCCC	45.68	21890473
83	Phosphorylation	RGNLAHCYSAEELVH CCCCCCCCCHHHHHH	10.88	29449344
84	Phosphorylation	GNLAHCYSAEELVHR CCCCCCCCHHHHHHH	34.30	29496963
98	Phosphorylation	RDCLQAPSAAGVPGD HHHHHCCHHCCCCCC	33.49	-
110	Phosphorylation	PGDVLAKSSANVYHH CCCEEECCCCCCCCC	29.13	27642862
110	O-linked_Glycosylation	PGDVLAKSSANVYHH CCCEEECCCCCCCCC	29.13	30059200
119	Phosphorylation	ANVYHHPTPAVSSNF CCCCCCCCCCCCCCC	21.37	-
127	Phosphorylation	PAVSSNFYSTVGRNG CCCCCCCCCCCCCCC	14.00	27642862
167	Acetylation	PGDKSAEKGPPAATA CCCCCCCCCCCCHHH	76.16	26051181
218	Phosphorylation	ERRRRPESSSSPESS HHHHCCCCCCCCCCC	37.90	20873877
219	Phosphorylation	RRRRPESSSSPESSS HHHCCCCCCCCCCCC	32.92	20873877
220	Phosphorylation	RRRPESSSSPESSSG HHCCCCCCCCCCCCC	60.22	20873877
221	Phosphorylation	RRPESSSSPESSSGH HCCCCCCCCCCCCCC	34.33	20873877
224	Phosphorylation	ESSSSPESSSGHTED CCCCCCCCCCCCCCC	32.94	20873877
225	Phosphorylation	SSSSPESSSGHTEDK CCCCCCCCCCCCCCC	38.38	20873877
226	Phosphorylation	SSSPESSSGHTEDKA CCCCCCCCCCCCCCC	43.82	20873877
229	Phosphorylation	PESSSGHTEDKAGGS CCCCCCCCCCCCCCC	49.78	20873877
237	Phosphorylation	EDKAGGSSGQRTRKK CCCCCCCCCCCCCCC	42.07	24505115
241	Phosphorylation	GGSSGQRTRKKRCPY CCCCCCCCCCCCCCC	38.66	24505115
281	Phosphorylation	LSRMLNLTDRQVKIW HHHHHCCCHHHHHHH	28.23	18767875

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
98	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
119	T	Phosphorylation	Kinase	PRKDC	P78527	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXA11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXA11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TYY1_HUMAN	YY1	physical	16963455
HDAC2_HUMAN	HDAC2	physical	16963455
HDAC1_HUMAN	HDAC1	physical	16963455
PGBD3_HUMAN	PGBD3	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 605432: Radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.