dbPTM

HSFA2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSFA2_ARATH
UniProt AC	O80982
Protein Name	Heat stress transcription factor A-2
Gene Name	HSFA2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	345
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs)..
Protein Sequence	MEELKVEMEEETVTFTGSVAASSSVGSSSSPRPMEGLNETGPPPFLTKTYEMVEDPATDTVVSWSNGRNSFVVWDSHKFSTTLLPRYFKHSNFSSFIRQLNTYGFRKIDPDRWEFANEGFLAGQKHLLKNIKRRRNMGLQNVNQQGSGMSCVEVGQYGFDGEVERLKRDHGVLVAEVVRLRQQQHSSKSQVAAMEQRLLVTEKRQQQMMTFLAKALNNPNFVQQFAVMSKEKKSLFGLDVGRKRRLTSTPSLGTMEENLLHDQEFDRMKDDMEMLFAAAIDDEANNSMPTKEEQCLEAMNVMMRDGNLEAALDVKVEDLVGSPLDWDSQDLHDMVDQMGFLGSEP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
167	Sumoylation	DGEVERLKRDHGVLV CCCHHHHHHHHCEEH	63.10	-
315	Sumoylation	LEAALDVKVEDLVGS HHHHEEEEHHHHCCC	39.30	-
315	Sumoylation	LEAALDVKVEDLVGS HHHHEEEEHHHHCCC	39.30	20521085

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HSFA2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
315	K	Sumoylation		20521085
Sumoylated at Lys-315.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSFA2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSFA2_ARATH	HSFA2	physical	20458611
HFA1A_ARATH	HSF1	physical	20458611
HFA1B_ARATH	HSF3	physical	20458611
HS901_ARATH	HSP90.1	physical	19366428

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSFA2_ARATH

Related Literatures of Post-Translational Modification

Sumoylation
Reference	PubMed
"Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modifies itsactivity during acquired thermotholerance."; Cohen-Peer R., Schuster S., Meiri D., Breiman A., Avni A.; Plant Mol. Biol. 74:33-45(2010). Cited for: INTERACTION WITH SUMO1, SUBCELLULAR LOCATION, SUMOYLATION AT LYS-315,DISRUPTION PHENOTYPE, AND MUTAGENESIS OF LYS-5; LYS-167; LYS-269 ANDLYS-315.	20521085 [Abstract]