HGFL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HGFL_HUMAN
• UniProt AC: P26927
• Protein Name: Hepatocyte growth factor-like protein
• Gene Name: MST1
• Organism: Homo sapiens (Human).
• Sequence Length: 711
• Subcellular Localization: Secreted.
• Protein Sequence: MGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRCGPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LPLLLLLTQCLGVPG HHHHHHHHHHHCCCC	19.73	24043423
72	N-linked_Glycosylation	DCRAFHYNVSSHGCQ CHHHCCEECCCCCEE	20.72	UniProtKB CARBOHYD
86	N-linked_Glycosylation	QLLPWTQHSPHTRLR EECCCCCCCCCCCCC	35.60	10068459
185	Phosphorylation	FQSCGIKSCREAACV CCCCCCCHHHHEEEE	19.24	21214269
199	Phosphorylation	VWCNGEEYRGAVDRT EEECCCEECCCCCCC	15.28	21214269
213	Phosphorylation	TESGRECQRWDLQHP CCCCCCCCCCCCCCC	44.75	-
296	N-linked_Glycosylation	EGYRGTANTTTAGVP CCCCCCCCCCCCCCC	37.48	16335952
310	N-linked_Glycosylation	PCQRWDAQIPHQHRF CCCCCCCCCCCCCCC	47.47	16335952
310	N-linked_Glycosylation	PCQRWDAQIPHQHRF CCCCCCCCCCCCCCC	47.47	16335952
345	Phosphorylation	SEAPWCFTLRPGMRA CCCCCEEEECCCCHH	20.79	24719451
407	O-linked_Glycosylation	HKPQFTFTSEPHAQL CCCCCEECCCCCCHH	29.17	OGP
480	Phosphorylation	DRLDQRRSKLRVVGG HHHHHHHHCEEEECC	37.93	-
551	Phosphorylation	NPQHGEPSLQRVPVA CCCCCCCCHHHCCEE	32.60	26091039
587	Ubiquitination	LNQRVALICLPPEWY CCCEEEEEEECCCEE	1.31	-
615	N-linked_Glycosylation	GETKGTGNDTVLNVA CCCCCCCCCCHHHHH	41.43	19159218
629	N-linked_Glycosylation	ALLNVISNQECNIKH HHHHHHCCCCCCCCC	30.46	19159218
629	N-linked_Glycosylation	ALLNVISNQECNIKH HHHHHHCCCCCCCCC	30.46	19159218

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HGFL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HGFL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HGFL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOXO1_HUMAN	FOXO1	physical	18786403
TNNI3_HUMAN	TNNI3	physical	18986304
TNNC1_HUMAN	TNNC1	physical	18986304
TNNT2_HUMAN	TNNT2	physical	18986304

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-615, AND MASSSPECTROMETRY.
PubMed: 19159218

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-296, AND MASSSPECTROMETRY.
PubMed: 16335952