GTR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTR2_HUMAN
• UniProt AC: P11168
• Protein Name: Solute carrier family 2, facilitated glucose transporter member 2
• Gene Name: SLC2A2
• Organism: Homo sapiens (Human).
• Sequence Length: 524
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney..
• Protein Sequence: MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MTEDKVTGTLVFTV -CCCCCCCCCHHHHH	30.14	26074081
9	Phosphorylation	TEDKVTGTLVFTVIT CCCCCCCCHHHHHHH	15.47	26074081
62	N-linked_Glycosylation	AINNYVINSTDELPT HHHHHCCCCCCCCCC	28.90	UniProtKB CARBOHYD
69	O-linked_Glycosylation	NSTDELPTISYSMNP CCCCCCCCEEEECCC	34.87	OGP
164	Phosphorylation	GRSISGLYCGLISGL CCCHHHHHHHHHHCC	6.49	25839225
169	Phosphorylation	GLYCGLISGLVPMYI HHHHHHHHCCCHHHH	30.99	25839225
175	Phosphorylation	ISGLVPMYIGEIAPT HHCCCHHHHHHHHHH	10.33	25839225
225	Phosphorylation	WHILLGLSGVRAILQ HHHHHHHHHHHHHHH	33.18	24719451
284	Phosphorylation	RKEREEASSEQKVSI HHHHHHCCHHHCEEE	37.37	29083192
285	Phosphorylation	KEREEASSEQKVSII HHHHHCCHHHCEEEE	51.61	29083192
290	Phosphorylation	ASSEQKVSIIQLFTN CCHHHCEEEEHHHCC	22.47	29083192
296	Phosphorylation	VSIIQLFTNSSYRQP EEEEHHHCCCCCCHH	42.66	29083192
298	Phosphorylation	IIQLFTNSSYRQPIL EEHHHCCCCCCHHHH	26.20	29083192
299	Phosphorylation	IQLFTNSSYRQPILV EHHHCCCCCCHHHHH	26.80	29083192
300	Phosphorylation	QLFTNSSYRQPILVA HHHCCCCCCHHHHHH	17.06	29083192
491	Phosphorylation	VPETKGKSFEEIAAE CCCCCCCCHHHHHHH	46.70	8626492
503	Phosphorylation	AAEFQKKSGSAHRPK HHHHHHHHCCCCCCC	45.04	8626492
505	Phosphorylation	EFQKKSGSAHRPKAA HHHHHHCCCCCCCHH	28.17	8626492
521	Phosphorylation	EMKFLGATETV---- EEHCCCCCCCC----	30.32	30257219
523	Phosphorylation	KFLGATETV------ HCCCCCCCC------	27.45	11044475

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
491	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
491	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
503	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
503	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
505	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
505	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GTR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMA1_HUMAN	KPNA2	physical	11988093
A4_HUMAN	APP	physical	21832049
TRUB1_HUMAN	TRUB1	physical	28514442
APOB_HUMAN	APOB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00069: Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD typ
• OMIM Disease
• 227810: Fanconi-Bickel syndrome (FBS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00428: Streptozocin