GSC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSC_MOUSE
• UniProt AC: Q02591
• Protein Name: Homeobox protein goosecoid
• Gene Name: Gsc
• Organism: Mus musculus (Mouse).
• Sequence Length: 256
• Subcellular Localization: Nucleus.
• Protein Description: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity)..
• Protein Sequence: MPASMFSIDNILAARPRCKDAVLPVAPSAAAPVVFPALHGDSLYGAGGGTSSDYGAFYPRPVAPGGAGLPAAVGSSRLGYNSYFYGQLHVQAAPVGPACCGAVPPLGAQQCSCVPTPPGYEGPGSVLVSPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARKVHLREEKVEVWFKNRRAKWRRQKRSSSEESENAEKWNKTSSKASPEKREEEGKSDLDSDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
183	Sumoylation	ENLFQETKYPDVGTR HHHHHHHCCCCCCCH	54.77	-
183	Sumoylation	ENLFQETKYPDVGTR HHHHHHHCCCCCCCH	54.77	-
196	Sumoylation	TREQLARKVHLREEK CHHHHHHHHHCCHHH	28.53	-
196	Sumoylation	TREQLARKVHLREEK CHHHHHHHHHCCHHH	28.53	-
203	Sumoylation	KVHLREEKVEVWFKN HHHCCHHHHHHHHHC	38.65	-
203	Sumoylation	KVHLREEKVEVWFKN HHHCCHHHHHHHHHC	38.65	-
209	Sumoylation	EKVEVWFKNRRAKWR HHHHHHHHCHHHHHH	33.56	-
209	Sumoylation	EKVEVWFKNRRAKWR HHHHHHHHCHHHHHH	33.56	-
214	Sumoylation	WFKNRRAKWRRQKRS HHHCHHHHHHHHHCC	39.15	-
214	Sumoylation	WFKNRRAKWRRQKRS HHHCHHHHHHHHHCC	39.15	-
238	Sumoylation	KWNKTSSKASPEKRE HHHHHCCCCCHHHHH	53.29	-
238	Sumoylation	KWNKTSSKASPEKRE HHHHHCCCCCHHHHH	53.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSC_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBX21_MOUSE	Tbx21	physical	20211142
WWP2_MOUSE	Wwp2	physical	21170031
FOXH1_MOUSE	Foxh1	physical	17568773

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.