GSAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSAP_HUMAN
• UniProt AC: A4D1B5
• Protein Name: Gamma-secretase-activating protein
• Gene Name: GSAP
• Organism: Homo sapiens (Human).
• Sequence Length: 854
• Subcellular Localization: Golgi apparatus, trans-Golgi network .
• Protein Description: Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD..
• Protein Sequence: MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQFRIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMFEVPLDISLSNSGFKLVNFGCDYHQYRDKFSKHLTLCVFTNHTGSLCVCYSPKCASWGQITYSVFYIHKGHSKTFTTSLENVGSHMTKGITFLNLDYYVAVYLPGHFFHLLNVQHPDLICHNLFLTGNNEMIDMLPHCPLQSLSGSLVLDCCSGKLYRALLSQSSLLQLLQNTCLDCEKMAALHCALYCGQGAQFLEAQIIQWISENVSACHSFDLIQEFIIASSYWSVYSETSNMDKLLPHSSVLTWNTEIPGITLVTEDIALPLMKVLSFKGYWEKLNSNLEYVKYAKPHFHYNNSVVRREWHNLISEEKTGKRRSAAYVRNILDNAVKVISNLEARNLGPRLTPLLQEEDSHQRLLMGLMVSELKDHFLRHLQGVEKKKIEQMVLDYISKLLDLICHIVETNWRKHNLHSWVLHFNSRGSAAEFAVFHIMTRILEATNSLFLPLPPGFHTLHTILGVQCLPLHNLLHCIDSGVLLLTETAVIRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPMSSNIISRNHVTRLLQNYKKQPRNSMINKSSFSVEFLPLNYFIEILTDIESSNQALYPFEGHDNVDAEFVEEAALKHTAMLLGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
107	Phosphorylation	ERTLLAASLVQSTKE HHHHHHHHHHHHCCC	24.38	-
112	Phosphorylation	AASLVQSTKEGKRNE HHHHHHHCCCCCCCC	18.94	-
197	Phosphorylation	NRVVIKNSGHLPRDR CEEEEECCCCCCCCC	23.69	-
231	Phosphorylation	IDLKKSRSILKCIQF EEHHHCHHHHHHHHH	39.09	24719451
282	Phosphorylation	DKFSKHLTLCVFTNH HHHHCCEEEEEEECC	20.17	-
292	Phosphorylation	VFTNHTGSLCVCYSP EEECCCCCEEEEECC	21.54	24667141
319	Phosphorylation	FYIHKGHSKTFTTSL EEEECCCCCEEEECC	41.90	-
506	Phosphorylation	IPGITLVTEDIALPL CCCEEEEECCCHHHH	30.93	-
518	Phosphorylation	LPLMKVLSFKGYWEK HHHHHHHCCCHHHHH	28.09	24719451
593	Phosphorylation	RNLGPRLTPLLQEED HCCCCCCHHHHCCCC	17.11	24719451
612	Phosphorylation	LLMGLMVSELKDHFL HHHHHHHHHHHHHHH	24.20	24719451
772	Phosphorylation	RLWDHPMSSNIISRN HHCCCCCCCCCCCHH	25.37	25954137
773	Phosphorylation	LWDHPMSSNIISRNH HCCCCCCCCCCCHHH	26.29	25954137
777	Phosphorylation	PMSSNIISRNHVTRL CCCCCCCCHHHHHHH	24.19	25954137
782	Phosphorylation	IISRNHVTRLLQNYK CCCHHHHHHHHHHHC	14.19	25954137
788	Phosphorylation	VTRLLQNYKKQPRNS HHHHHHHHCCCCCCC	13.45	25954137

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSAP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSN1_HUMAN	PSEN1	physical	20811458
PEN2_HUMAN	PSENEN	physical	20811458
NICA_HUMAN	NCSTN	physical	20811458
A4_HUMAN	APP	physical	20811458
A4_HUMAN	APP	physical	25555914

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.