GRIK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRIK1_HUMAN
• UniProt AC: P39086
• Protein Name: Glutamate receptor ionotropic, kainate 1
• Gene Name: GRIK1
• Organism: Homo sapiens (Human).
• Sequence Length: 918
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus..
• Protein Sequence: MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECGKLIREERGIRKQSSVHTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	LAQPGLWTRDTSWAL ECCCCCCCCCHHHHH	24.57	24043423
68	N-linked_Glycosylation	AVTSINRNRTLMPNT HHHCCCCCCCCCCCC	36.48	UniProtKB CARBOHYD
74	N-linked_Glycosylation	RNRTLMPNTTLTYDI CCCCCCCCCEEEEEE	31.56	UniProtKB CARBOHYD
147	Phosphorylation	VDNKDLFYINLYPDY CCCCCEEEEEECCCH	9.01	24043423
151	Phosphorylation	DLFYINLYPDYAAIS CEEEEEECCCHHHHH	6.92	24043423
154	Phosphorylation	YINLYPDYAAISRAI EEEECCCHHHHHHHH	8.07	24043423
158	Phosphorylation	YPDYAAISRAILDLV CCCHHHHHHHHHHHH	15.78	24043423
276	N-linked_Glycosylation	LYRYSGVNMTGFRLL HHHHCCCCCCCEEEE	26.31	UniProtKB CARBOHYD
291	Phosphorylation	NIDNPHVSSIIEKWS CCCCCCHHHHHHHHC	16.88	26074081
292	Phosphorylation	IDNPHVSSIIEKWSM CCCCCHHHHHHHHCH	26.88	26074081
310	Phosphorylation	QAPPRPETGLLDGMM CCCCCCCCCCCCCCC	35.49	22210691
318	Phosphorylation	GLLDGMMTTEAALMY CCCCCCCHHHHHHHH	16.76	22210691
319	Phosphorylation	LLDGMMTTEAALMYD CCCCCCHHHHHHHHH	13.01	22210691
325	Phosphorylation	TTEAALMYDAVYMVA HHHHHHHHHHHHHHH	11.12	22210691
329	Phosphorylation	ALMYDAVYMVAIASH HHHHHHHHHHHHHHH	6.39	22210691
379	N-linked_Glycosylation	LTGHITFNKTNGLRK CCEEEEEECCCCCCC	41.41	UniProtKB CARBOHYD
386	Methylation	NKTNGLRKDFDLDII ECCCCCCCCCEEEEE	68.72	-
386	"N6,N6-dimethyllysine"	NKTNGLRKDFDLDII ECCCCCCCCCEEEEE	68.72	-
394	Phosphorylation	DFDLDIISLKEEGTE CCEEEEEEECCCCCH	33.45	24719451
396	"N6,N6-dimethyllysine"	DLDIISLKEEGTEKA EEEEEEECCCCCHHH	47.10	-
396	Methylation	DLDIISLKEEGTEKA EEEEEEECCCCCHHH	47.10	-
423	Phosphorylation	KKIGIWNSNSGLNMT HHHCCEECCCCCCCC	19.85	22617229
428	N-linked_Glycosylation	WNSNSGLNMTDSNKD EECCCCCCCCCCCCC	34.53	UniProtKB CARBOHYD
430	Phosphorylation	SNSGLNMTDSNKDKS CCCCCCCCCCCCCCC	34.89	22617229
432	Phosphorylation	SGLNMTDSNKDKSSN CCCCCCCCCCCCCCC	36.29	24850871
439	N-linked_Glycosylation	SNKDKSSNITDSLAN CCCCCCCCHHHHHHC	48.55	UniProtKB CARBOHYD
446	N-linked_Glycosylation	NITDSLANRTLIVTT CHHHHHHCCEEEEEE	42.64	UniProtKB CARBOHYD
487	Phosphorylation	LDLLKELSNILGFIY HHHHHHHHHHHHHHC	23.94	22496350
494	Phosphorylation	SNILGFIYDVKLVPD HHHHHHHCEEEECCC	16.66	19835603
561	N-linked_Glycosylation	SILYRKPNGTNPGVF EEEEECCCCCCCCHH	73.32	UniProtKB CARBOHYD
681	Phosphorylation	LTVERMESPIDSADD HCHHCCCCCCCCHHH	20.15	-
685	Phosphorylation	RMESPIDSADDLAKQ CCCCCCCCHHHHHHH	34.03	-
704	Phosphorylation	YGAVRDGSTMTFFKK EECCCCCCEEEEEEH	21.21	-
715	Phosphorylation	FFKKSKISTYEKMWA EEEHHCCCHHHHHHH	28.77	22617229
725	Phosphorylation	EKMWAFMSSRQQTAL HHHHHHHHHHCCEEE	18.86	-
761	Phosphorylation	STSIEYVTQRNCNLT HCCHHHHHCCCCCCE	22.40	-
766	N-linked_Glycosylation	YVTQRNCNLTQIGGL HHHCCCCCCEEECCE	50.07	-
861	Phosphorylation	IGEFIYKSRKNNDIE HHHHHHHHCCCCCHH	31.36	-
879 (in isoform 2)	Phosphorylation	-	4.19	-
885 (in isoform 2)	Phosphorylation	-	33.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
725	S	Phosphorylation	Kinase	PKC	-	Uniprot
761	T	Phosphorylation	Kinase	PKC	-	Uniprot
879	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
885	S	Phosphorylation	Kinase	PRKCA	P05696	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRIK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRIK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PICK1_HUMAN	PICK1	physical	12597860
SDCB1_HUMAN	SDCBP	physical	12597860
DLG4_HUMAN	DLG4	physical	12597860
GRIP1_HUMAN	GRIP1	physical	12597860

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00537: Topiramate (JAN/USAN/INN); Topamax (TN); Trokendi xr (TN)
• D02546: Kainic acid hydrate (JP16); Digenin (TN)
• D06656: Tezampanel (USAN); Tezampanel hydrate
• DrugBank
• DB00273: Topiramate