GRHL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRHL2_HUMAN
• UniProt AC: Q6ISB3
• Protein Name: Grainyhead-like protein 2 homolog
• Gene Name: GRHL2
• Organism: Homo sapiens (Human).
• Sequence Length: 625
• Subcellular Localization: Nucleus . Membrane . detected at cell-cell contact areas.
• Protein Description: Transcription factor playing an important role in primary neurulation and in epithelial development. [PubMed: 29309642]
• Protein Sequence: MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKVTLMEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQESDNNK ------CCCCCCCCC	42.53	22210691
5	Phosphorylation	---MSQESDNNKRLV ---CCCCCCCCCEEE	37.69	22210691
30	Phosphorylation	FNTRRAYTSEDEAWK CCCCCCCCCCHHHHH	25.34	23090842
31	Phosphorylation	NTRRAYTSEDEAWKS CCCCCCCCCHHHHHH	30.30	28985074
53	Phosphorylation	AATKAMMSINGDEDS HHHHHHHHCCCCHHH	10.38	-
60	Phosphorylation	SINGDEDSAAALGLL HCCCCHHHHHHHHHH	20.12	28348404
68	Phosphorylation	AAALGLLYDYYKVPR HHHHHHHHHHHHCCC	13.62	-
70	Phosphorylation	ALGLLYDYYKVPRDK HHHHHHHHHHCCCCH	7.51	-
71	Phosphorylation	LGLLYDYYKVPRDKR HHHHHHHHHCCCCHH	11.56	-
81	Phosphorylation	PRDKRLLSVSKASDS CCCHHCEEEECCCCC	29.01	25056879
83	Phosphorylation	DKRLLSVSKASDSQE CHHCEEEECCCCCHH	21.09	28102081
88	Phosphorylation	SVSKASDSQEDQEKR EEECCCCCHHHHHHH	32.73	-
105	Phosphorylation	LGTSEAQSNLSGGEN CCCHHHHHHCCCCCC	46.95	25849741
108	Phosphorylation	SEAQSNLSGGENRVQ HHHHHHCCCCCCEEE	49.34	28348404
125	Phosphorylation	KTVPVNLSLNQDHLE EEEEEEEECCHHHHH	21.77	24719451
164	Phosphorylation	VVKAEDFTPVFMAPP EEEECCCCCEEECCC	30.75	25106551
192	Phosphorylation	VIFEQTQYDVPSLAT EEEEECCCCCCCHHC	23.46	27642862
210	Phosphorylation	YLKDDQRSTPDSTYS ECCCCCCCCCCCCCC	38.36	30278072
211	Phosphorylation	LKDDQRSTPDSTYSE CCCCCCCCCCCCCCH	33.05	30278072
214	Phosphorylation	DQRSTPDSTYSESFK CCCCCCCCCCCHHHH	30.37	25849741
215	Phosphorylation	QRSTPDSTYSESFKD CCCCCCCCCCHHHHH	38.15	25849741
216	Phosphorylation	RSTPDSTYSESFKDA CCCCCCCCCHHHHHH	17.88	27251275
217	Phosphorylation	STPDSTYSESFKDAA CCCCCCCCHHHHHHH	27.18	23090842
219	Phosphorylation	PDSTYSESFKDAATE CCCCCCHHHHHHHHH	31.49	23090842
230	Phosphorylation	AATEKFRSASVGAEE HHHHHHHHCCCCCEE	28.20	27251275
232	Phosphorylation	TEKFRSASVGAEEYM HHHHHHCCCCCEEEE	23.48	27251275
238	Phosphorylation	ASVGAEEYMYDQTSS CCCCCEEEEEECCCC	7.77	19845377
243	Phosphorylation	EEYMYDQTSSGTFQY EEEEEECCCCCEEEE	23.20	19845377
319	Phosphorylation	EQLKYWKYWHSRQHT HHHHHHHHHHHCCCC	8.33	24719451
326	Phosphorylation	YWHSRQHTAKQRVLD HHHHCCCCHHHHHHH	27.49	24719451
370	Phosphorylation	EEAKIFITVNCLSTD CCCEEEEEEECCCCC	8.56	29083192
375	Phosphorylation	FITVNCLSTDFSSQK EEEEECCCCCCCCCC	28.29	29083192
376	Phosphorylation	ITVNCLSTDFSSQKG EEEECCCCCCCCCCC	28.28	29083192
379	Phosphorylation	NCLSTDFSSQKGVKG ECCCCCCCCCCCCCC	34.37	29083192
380	Phosphorylation	CLSTDFSSQKGVKGL CCCCCCCCCCCCCCC	35.59	29083192
401	Methylation	DTYSYNNRSNKPIHR ECCCCCCCCCCCCEE	37.66	-
497	Phosphorylation	LQRTGQVYYNTDDER CEECCCEEECCCCCC	5.32	28176443
498	Phosphorylation	QRTGQVYYNTDDERE EECCCEEECCCCCCC	16.84	30278072
500	Phosphorylation	TGQVYYNTDDEREGG CCCEEECCCCCCCCC	28.80	30278072
508	Phosphorylation	DDEREGGSVLVKRMF CCCCCCCEEEEEECC	24.12	28176443
512	Acetylation	EGGSVLVKRMFRPME CCCEEEEEECCCCCC	33.70	20167786
528	Acetylation	EFGPVPSKQMKEEGT HHCCCCCHHHCCCCC	48.63	19817357
531	Acetylation	PVPSKQMKEEGTKRV CCCCHHHCCCCCEEE	50.55	7708337
536	Acetylation	QMKEEGTKRVLLYVR HHCCCCCEEEEEEEE	51.90	7708347
568	Phosphorylation	KGLMEAISEKYGLPV HHHHHHHHHHHCCCH	34.77	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRHL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRHL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRHL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
GRHL1_HUMAN	GRHL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608641: Deafness, autosomal dominant, 28 (DFNA28)
• 616029: Ectodermal dysplasia/short stature syndrome (ECTDS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.