GPSM2_HUMAN - dbPTM
GPSM2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPSM2_HUMAN
UniProt AC P81274
Protein Name G-protein-signaling modulator 2
Gene Name GPSM2
Organism Homo sapiens (Human).
Sequence Length 684
Subcellular Localization Cytoplasm . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton, spindle pole . Lateral cell membrane . Localizes in the cytoplasm during interphase and at cell cortex during metaphase (PubMed:11781568, PubMed:15632202, PubMed:22074847). Colocalizes wit
Protein Description Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. [PubMed: 11781568]
Protein Sequence MEENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPEKVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADEDFFDILVKCQGSRLDDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQNRDTDFGLKDFLQNNALLEFKNSGKKSADH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MEENLISMREDHSF
-CCCCCCCCCCCCCE		18.2326552605
13PhosphorylationISMREDHSFHVRYRM
CCCCCCCCEEEEHHH		29.3926552605
84PhosphorylationDYAKALEYHHHDLTL
HHHHHHHHHHCCHHH		13.8027642862
90PhosphorylationEYHHHDLTLARTIGD
HHHHCCHHHHHHHHH		25.1624719451
103UbiquitinationGDQLGEAKASGNLGN
HHHHCCHHHCCCCHH		38.4921906983
113UbiquitinationGNLGNTLKVLGNFDE
CCCHHHHHHCCCCHH		33.12-
132PhosphorylationCQRHLDISRELNDKV
HHHHHHHHHHHHHHH		21.26-
146PhosphorylationVGEARALYNLGNVYH
HHHHHHHHHCCCEEE		13.8328152594
152PhosphorylationLYNLGNVYHAKGKSF
HHHCCCEEECCCCCC		10.4827642862
233UbiquitinationEQRLLIAKEFGDKAA
HHHHHHHHHHCHHHH		46.73-
238UbiquitinationIAKEFGDKAAERRAY
HHHHHCHHHHHHHHH		50.29-
252PhosphorylationYSNLGNAYIFLGEFE
HHCCCCEEEEEEECH		9.01-
264PhosphorylationEFETASEYYKKTLLL
ECHHHHHHHHHHHHH		20.35-
265PhosphorylationFETASEYYKKTLLLA
CHHHHHHHHHHHHHH		11.27-
268PhosphorylationASEYYKKTLLLARQL
HHHHHHHHHHHHHHH		20.6324114839
286PhosphorylationAVEAQSCYSLGNTYT
HHHHHHHHHCCCHHH		16.5122817900
298PhosphorylationTYTLLQDYEKAIDYH
HHHHHHHHHHHHHHH		13.3322817900
304PhosphorylationDYEKAIDYHLKHLAI
HHHHHHHHHHHHHHH		11.7022817900
352PhosphorylationAEKHLEISREVGDKS
HHHHHHHHHHHHCCC		17.02-
408PhosphorylationPKLGRRHSMENMELM
CCCCCCCCHHCHHHH		26.4423401153
418PhosphorylationNMELMKLTPEKVQNW
CHHHHHCCHHHHHCC		24.7126055452
427PhosphorylationEKVQNWNSEILAKQK
HHHHCCCHHHHHHCC		20.0322817900
441PhosphorylationKPLIAKPSAKLLFVN
CCCCCCCCCEEEEEE		37.0122817900
457PhosphorylationLKGKKYKTNSSTKVL
CCCCCCCCCCCCHHH		36.9220589935
459PhosphorylationGKKYKTNSSTKVLQD
CCCCCCCCCCHHHHH		44.6222817900
460PhosphorylationKKYKTNSSTKVLQDA
CCCCCCCCCHHHHHH		34.0321712546
461PhosphorylationKYKTNSSTKVLQDAS
CCCCCCCCHHHHHHH		25.6229214152
462UbiquitinationYKTNSSTKVLQDASN
CCCCCCCHHHHHHHH		42.78-
468PhosphorylationTKVLQDASNSIDHRI
CHHHHHHHHCCCCCC		39.1224719451
470PhosphorylationVLQDASNSIDHRIPN
HHHHHHHCCCCCCCC		27.2222817900
476PhosphorylationNSIDHRIPNSQRKIS
HCCCCCCCCCCCCCC		34.0818669648
478PhosphorylationIDHRIPNSQRKISAD
CCCCCCCCCCCCCCC		26.4722817900
479PhosphorylationDHRIPNSQRKISADT
CCCCCCCCCCCCCCC		58.2718669648
481UbiquitinationRIPNSQRKISADTIG
CCCCCCCCCCCCCCC		33.12-
483PhosphorylationPNSQRKISADTIGDE
CCCCCCCCCCCCCCC		24.1123927012
486PhosphorylationQRKISADTIGDEGFF
CCCCCCCCCCCCCHH		26.9523927012
497PhosphorylationEGFFDLLSRFQSNRM
CCHHHHHHHHHHCCC		38.0423312004
501PhosphorylationDLLSRFQSNRMDDQR
HHHHHHHHCCCCHHH		24.56-
518PhosphorylationLQEKNCHTASTTTSS
CCCCCCCCCCCCCCC		25.2220068231
520PhosphorylationEKNCHTASTTTSSTP
CCCCCCCCCCCCCCC		27.6928450419
521PhosphorylationKNCHTASTTTSSTPP
CCCCCCCCCCCCCCC		31.4628450419
522PhosphorylationNCHTASTTTSSTPPK
CCCCCCCCCCCCCCC		23.3728450419
523PhosphorylationCHTASTTTSSTPPKM
CCCCCCCCCCCCCCE		22.2928450419
524PhosphorylationHTASTTTSSTPPKMM
CCCCCCCCCCCCCEE		30.0728450419
525PhosphorylationTASTTTSSTPPKMML
CCCCCCCCCCCCEEE		42.7228450419
526PhosphorylationASTTTSSTPPKMMLK
CCCCCCCCCCCEEEE		43.2925849741
534PhosphorylationPPKMMLKTSSVPVVS
CCCEEEECCCCCEEC		23.4424732914
535PhosphorylationPKMMLKTSSVPVVSP
CCEEEECCCCCEECC		27.9624732914
536PhosphorylationKMMLKTSSVPVVSPN
CEEEECCCCCEECCC		35.3524732914
537PhosphorylationMMLKTSSVPVVSPNT
EEEECCCCCEECCCH		4.1218669648
541PhosphorylationTSSVPVVSPNTDEFL
CCCCCEECCCHHHHH		16.8021712546
544PhosphorylationVPVVSPNTDEFLDLL
CCEECCCHHHHHHHH		40.0522617229
553PhosphorylationEFLDLLASSQSRRLD
HHHHHHHHHCCCCHH		28.9526074081
554PhosphorylationFLDLLASSQSRRLDD
HHHHHHHHCCCCHHH		26.9422817900
556PhosphorylationDLLASSQSRRLDDQR
HHHHHHCCCCHHHHH		22.7024732914
565PhosphorylationRLDDQRASFSNLPGL
CHHHHHHHHCCCCCC		31.2530266825
567PhosphorylationDDQRASFSNLPGLRL
HHHHHHHCCCCCCCC		34.6530266825
575PhosphorylationNLPGLRLTQNSQSVL
CCCCCCCCCCHHHHH		21.1926074081
578PhosphorylationGLRLTQNSQSVLSHL
CCCCCCCHHHHHHHH		17.6426074081
580PhosphorylationRLTQNSQSVLSHLMT
CCCCCHHHHHHHHHC		25.5026074081
583PhosphorylationQNSQSVLSHLMTNDN
CCHHHHHHHHHCCCC		16.6626074081
587PhosphorylationSVLSHLMTNDNKEAD
HHHHHHHCCCCHHCC		45.8626074081
607PhosphorylationILVKCQGSRLDDQRC
HHHHCCCCCCCCCCC		12.0922817900
633PhosphorylationVPDEDFFSLILRSQG
CCCHHHHHHHHHHHC		17.9422817900
638PhosphorylationFFSLILRSQGKRMDE
HHHHHHHHHCCCCCH		39.5822817900
658PhosphorylationQRDQNRDTDFGLKDF
HCCCCCCCCCCHHHH		29.9522817900
675UbiquitinationNNALLEFKNSGKKSA
HCCCEEEHHCCCCCC		40.61-
677PhosphorylationALLEFKNSGKKSADH
CCEEEHHCCCCCCCC		53.2122817900
681PhosphorylationFKNSGKKSADH----
EHHCCCCCCCC----		42.2720933426
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
132SPhosphorylationKinasePKG-Uniprot
352SPhosphorylationKinasePKG-Uniprot
408SPhosphorylationKinasePRKCAP17252
GPS
457TPhosphorylationKinasePBKQ96KB5
PSP
501SPhosphorylationKinasePKC-Uniprot
607SPhosphorylationKinasePKG-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPSM2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPSM2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GNAI3_HUMANGNAI3physical
12925752
GNAI2_HUMANGNAI2physical
12748287
RASH_HUMANHRASphysical
12748287
NUMA1_HUMANNUMA1physical
11781568
GNAI2_HUMANGNAI2physical
8973305
CALD1_HUMANCALD1physical
26496610
ECT2_HUMANECT2physical
26496610
TF3C2_HUMANGTF3C2physical
26496610
TTF1_HUMANTTF1physical
26496610
GEMI6_HUMANGEMIN6physical
26496610
ACSF4_HUMANAASDHphysical
26496610
LSM11_HUMANLSM11physical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
604213Chudley-McCullough syndrome (CMCS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPSM2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483; THR-486 ANDSER-541, AND MASS SPECTROMETRY.

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