GPIX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPIX_HUMAN
• UniProt AC: P14770
• Protein Name: Platelet glycoprotein IX
• Gene Name: GP9
• Organism: Homo sapiens (Human).
• Sequence Length: 177
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib..
• Protein Sequence: MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	DCRGHGLTALPALPA ECCCCCCCCCCCCCC	30.64	22617229
60	N-linked_Glycosylation	TRHLLLANNSLQSVP HHEEHHHCCCCCCCC	38.30	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPIX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPIX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPIX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBP2_HUMAN	APPBP2	physical	19060904
HXA1_HUMAN	HOXA1	physical	25416956
SPY2_HUMAN	SPRY2	physical	25416956
HXA1_HUMAN	HOXA1	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.