GNA14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNA14_HUMAN
• UniProt AC: O95837
• Protein Name: Guanine nucleotide-binding protein subunit alpha-14
• Gene Name: GNA14
• Organism: Homo sapiens (Human).
• Sequence Length: 355
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems..
• Protein Sequence: MAGCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRKGFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQNKENAQIIREVEVDKVSMLSREQVEAIKQLWQDPGIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLNSSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVRAARDFILKLYQDQNPDKEKVIYSHFTCATDTDNIRFVFAAVKDTILQLNLREFNLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	S-palmitoylation	----MAGCCCLSAEE ----CCCCEECCHHH	0.78	17620339
5	S-palmitoylation	---MAGCCCLSAEEK ---CCCCEECCHHHH	2.27	17620339
6	S-palmitoylation	--MAGCCCLSAEEKE --CCCCEECCHHHHH	3.80	17620339
8	Phosphorylation	MAGCCCLSAEEKESQ CCCCEECCHHHHHHH	21.51	30177828
36	Ubiquitination	KKDARRELKLLLLGT HHHHHHHHHHHHHHC	4.49	22817900
37	Ubiquitination	KDARRELKLLLLGTG HHHHHHHHHHHHHCC	32.13	30230243
46	Phosphorylation	LLLGTGESGKSTFIK HHHHCCCCCCHHHHE	53.52	-
48	Ubiquitination	LGTGESGKSTFIKQM HHCCCCCCHHHHEEE	56.45	30230243
49	Phosphorylation	GTGESGKSTFIKQMR HCCCCCCHHHHEEEE	31.88	17531806
53	Ubiquitination	SGKSTFIKQMRIIHG CCCHHHHEEEEEECC	33.57	30230243
76	Phosphorylation	KGFTKLVYQNIFTAM CCCHHHHHHHHHHHH	13.28	22817900
81	Phosphorylation	LVYQNIFTAMQAMIR HHHHHHHHHHHHHHH	19.88	23612710
92	Phosphorylation	AMIRAMDTLRIQYVC HHHHHHHHHHHHHHH	12.59	27259358
100	Ubiquitination	LRIQYVCEQNKENAQ HHHHHHHHHCHHHCE	47.33	22817900
147	Phosphorylation	CYDRRREYQLSDSAK HHHHHHHHCCCCCCC	16.97	-
150	Phosphorylation	RRREYQLSDSAKYYL HHHHHCCCCCCCEEE	17.62	22817900
154	Ubiquitination	YQLSDSAKYYLTDID HCCCCCCCEEECCHH	38.08	22817900
155	Phosphorylation	QLSDSAKYYLTDIDR CCCCCCCEEECCHHH	11.92	30576142
156	Phosphorylation	LSDSAKYYLTDIDRI CCCCCCEEECCHHHC	11.47	30576142
158	Phosphorylation	DSAKYYLTDIDRIAT CCCCEEECCHHHCCC	18.13	30576142
167	Phosphorylation	IDRIATPSFVPTQQD HHHCCCCCCCCCCCC	34.22	-
171	Phosphorylation	ATPSFVPTQQDVLRV CCCCCCCCCCCEEEE	33.29	-
179	ADP-ribosylation	QQDVLRVRVPTTGII CCCEEEEECCCCCEE	23.43	-
179	ADP-ribosylation	QQDVLRVRVPTTGII CCCEEEEECCCCCEE	23.43	-
183	Phosphorylation	LRVRVPTTGIIEYPF EEEECCCCCEEECCC	21.95	-
223	Ubiquitination	FESVTSIIFLVALSE HHHHHHHHHHHHHHH	1.88	22817900
281	Phosphorylation	LLEEKIMYSHLISYF HHHHHHHHHHHHHHC	9.08	25072903
282	Phosphorylation	LEEKIMYSHLISYFP HHHHHHHHHHHHHCC	8.40	25072903
286	Phosphorylation	IMYSHLISYFPEYTG HHHHHHHHHCCCCCC	27.38	25072903
287	Phosphorylation	MYSHLISYFPEYTGP HHHHHHHHCCCCCCC	19.03	25072903
287	Ubiquitination	MYSHLISYFPEYTGP HHHHHHHHCCCCCCC	19.03	22817900
291	Phosphorylation	LISYFPEYTGPKQDV HHHHCCCCCCCHHHH	19.75	25072903
292	Phosphorylation	ISYFPEYTGPKQDVR HHHCCCCCCCHHHHH	45.40	25072903
341	Ubiquitination	RFVFAAVKDTILQLN EEEHHHHHHHHHHHH	44.41	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNA14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNA14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNA14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JMJD6_HUMAN	JMJD6	physical	23455924
DNAL4_HUMAN	DNAL4	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.