GLT13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLT13_HUMAN
• UniProt AC: Q8IUC8
• Protein Name: Polypeptide N-acetylgalactosaminyltransferase 13
• Gene Name: GALNT13
• Organism: Homo sapiens (Human).
• Sequence Length: 556
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells..
• Protein Sequence: MRRFVYCKVVLATSLMWVLVDVFLLLYFSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLDVSRLNGPVIMLKCHHMRGNQLWEYDAERLTLRHVNSNQCLDEPSEEDKMVPTMQDCSGSRSQQWLLRNMTLGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRRFVYCKVVLAT --CCCCHHHHHHHHH	5.48	25072903
13	Phosphorylation	YCKVVLATSLMWVLV HHHHHHHHHHHHHHH	20.45	25072903
14	Phosphorylation	CKVVLATSLMWVLVD HHHHHHHHHHHHHHH	15.60	25072903
94	N-linked_Glycosylation	ASDLIALNRSLPDVR HHHHHHHCCCCCCCE	23.60	UniProtKB CARBOHYD
116	N-linked_Glycosylation	VYPDELPNTSVVIVF ECCCCCCCCEEEEEE	58.57	UniProtKB CARBOHYD
323	Phosphorylation	GGENLEMSFRIWQCG CCCCCEEEEEEEECC	11.29	24719451
381	Phosphorylation	DEFKDFFYIISPGVV HHHHCEEEEECCCEE	9.42	-
392	Phosphorylation	PGVVKVDYGDVSVRK CCEEEECCCCCCHHH	20.43	-
551	N-linked_Glycosylation	SQQWLLRNMTLGT-- HHHHHHHHCCCCC--	27.97	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLT13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLT13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLT13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GALT1_HUMAN	GALNT1	physical	28514442
LRRC3_HUMAN	LRRC3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.