GGA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGA3_MOUSE
• UniProt AC: Q8BMI3
• Protein Name: ADP-ribosylation factor-binding protein GGA3
• Gene Name: Gga3
• Organism: Mus musculus (Mouse).
• Sequence Length: 718
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
• Protein Description: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity)..
• Protein Sequence: MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEAVQALTVLEACMKNCGRRLHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLFSWTLALPEEAKIKDAYHMLKRQGIVQSDPPIPMDRTLIPSPPPRPKNPVFDDEEKSKLLARLLKSKNPDDLQEANRLIKSMVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHYSQEYSSDADKELMKELFDRCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQIVNGEVTTSTMPDSEGNSHCGNQGALIDLAELDAPSNSSPALAPPTSGIPILPPPPQTSGPPRSRSSSQAEAPPGSDSTNNALSLLDEELLCLGLTDPAPTAPKESPGSSQWHLFQNEPPSDLDFFSPRPVPAASCPSDGPQLPPPVSTSSMSQAPLPAAFPAPVVPASAPTHSTGSFMFSSGPAPALAPKAEPKGPEYPSSSTSHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASAPARPLLPFSTGPGSPLFQSQGSPQKGPELSLASVHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGEQLSTELGEVDQFPPVEQWGNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAEAEGESLESWLNK CCCHHHHHHHHHHHH	48.57	28066266
15	Ubiquitination	SLESWLNKATNPSNR HHHHHHHHCCCCCCC	55.18	22790023
38	Ubiquitination	GFCDQINKELEGPQI HHHHHHHHHCCCHHH	66.36	-
100	Ubiquitination	LIKVVSPKYLGDRVS HHHHHCHHHCCHHHC	45.67	-
155	Phosphorylation	PPIPMDRTLIPSPPP CCCCCCCCCCCCCCC	25.44	28285833
159	Phosphorylation	MDRTLIPSPPPRPKN CCCCCCCCCCCCCCC	42.94	25521595
174	Ubiquitination	PVFDDEEKSKLLARL CCCCHHHHHHHHHHH	51.33	-
176	Ubiquitination	FDDEEKSKLLARLLK CCHHHHHHHHHHHHH	59.60	-
185	Ubiquitination	LARLLKSKNPDDLQE HHHHHHCCCHHHHHH	71.55	-
258	Ubiquitination	LFDRCENKRRTLFKL HHHHHHHHHHHHHHH	22.44	22790023
264	Ubiquitination	NKRRTLFKLASETED HHHHHHHHHHHCCCC	46.38	22790023
267	Phosphorylation	RTLFKLASETEDNDN HHHHHHHHCCCCCCC	56.33	29899451
269	Phosphorylation	LFKLASETEDNDNSL HHHHHHCCCCCCCCH	46.25	29899451
275	Phosphorylation	ETEDNDNSLGDILQA CCCCCCCCHHHHHHH	36.27	-
366	Phosphorylation	SGPPRSRSSSQAEAP CCCCCCCCCCCCCCC	35.27	24224561
367	Phosphorylation	GPPRSRSSSQAEAPP CCCCCCCCCCCCCCC	25.92	23649490
368	Phosphorylation	PPRSRSSSQAEAPPG CCCCCCCCCCCCCCC	34.36	28059163
384	Phosphorylation	DSTNNALSLLDEELL CCCCHHHHHCCHHHH	25.19	23649490
406	Phosphorylation	APTAPKESPGSSQWH CCCCCCCCCCCCCCE	40.46	21082442
544	Phosphorylation	ASPLLPASAPARPLL CCCCCCCCCCCCCCC	32.61	26643407
554	Phosphorylation	ARPLLPFSTGPGSPL CCCCCCCCCCCCCCC	30.43	26643407
555	Phosphorylation	RPLLPFSTGPGSPLF CCCCCCCCCCCCCCC	48.01	26643407
559	Phosphorylation	PFSTGPGSPLFQSQG CCCCCCCCCCCCCCC	22.89	26824392
564	Phosphorylation	PGSPLFQSQGSPQKG CCCCCCCCCCCCCCC	29.22	26643407
567	Phosphorylation	PLFQSQGSPQKGPEL CCCCCCCCCCCCCCC	19.27	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Nedd4	P46935	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGA3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARF1_MOUSE	Arf1	physical	24089482
FLNA_MOUSE	Flna	physical	24089482

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.