| UniProt ID | GFRA1_HUMAN | |
|---|---|---|
| UniProt AC | P56159 | |
| Protein Name | GDNF family receptor alpha-1 | |
| Gene Name | GFRA1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 465 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor. |
|
| Protein Description | Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).. | |
| Protein Sequence | MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 59 | N-linked_Glycosylation | CVAGKETNFSLASGL HHCCCCCCCCHHHCC | 26.12 | UniProtKB CARBOHYD | |
| 59 | N-linked_Glycosylation | CVAGKETNFSLASGL HHCCCCCCCCHHHCC | 26.12 | 19349973 | |
| 74 | Phosphorylation | EAKDECRSAMEALKQ CCHHHHHHHHHHHHH | 43.56 | 22210691 | |
| 139 | Phosphorylation | FRVVPFISDVFQQVE HHHHHHHHHHHHHHC | 28.27 | 27251275 | |
| 139 (in isoform 2) | Phosphorylation | - | 28.27 | 25849741 | |
| 183 | Phosphorylation | TPCTTSVSNDVCNRR CCCCCCCCCHHCCHH | 27.38 | 25849741 | |
| 347 | N-linked_Glycosylation | NAIQAFGNGSDVTVW HHHHHHCCCCCEEEE | 40.10 | UniProtKB CARBOHYD | |
| 349 | Phosphorylation | IQAFGNGSDVTVWQP HHHHCCCCCEEEEEC | 32.67 | 25954137 | |
| 352 | Phosphorylation | FGNGSDVTVWQPAFP HCCCCCEEEEECCCC | 22.48 | 25954137 | |
| 363 | Phosphorylation | PAFPVQTTTATTTTA CCCCCCCCEEEEEEE | 9.42 | 25954137 | |
| 369 | Phosphorylation | TTTATTTTALRVKNK CCEEEEEEEEEECCC | 22.92 | 25954137 | |
| 406 | N-linked_Glycosylation | QAQKLKSNVSGNTHL CHHHHHHCCCCCCEE | 30.32 | UniProtKB CARBOHYD | |
| 429 | GPI-anchor | KEGLGASSHITTKSM CCCCCCCCCCCCCCC | 20.55 | - | |
| 432 | O-linked_Glycosylation | LGASSHITTKSMAAP CCCCCCCCCCCCCCC | 23.81 | 55835555 | |
| 433 | O-linked_Glycosylation | GASSHITTKSMAAPP CCCCCCCCCCCCCCC | 22.10 | 55835561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GFRA1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GFRA1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GFRA1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GDNF_HUMAN | GDNF | physical | 9407096 | |
| NRTN_HUMAN | NRTN | physical | 9407096 | |
| GDNF_HUMAN | GDNF | physical | 10829012 | |
| NRTN_HUMAN | NRTN | physical | 10829012 | |
| SOCS3_HUMAN | SOCS3 | physical | 21988832 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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