| UniProt ID | GDF10_HUMAN | |
|---|---|---|
| UniProt AC | P55107 | |
| Protein Name | Growth/differentiation factor 10 | |
| Gene Name | GDF10 {ECO:0000312|HGNC:HGNC:4215} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 478 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.. | |
| Protein Sequence | MAHVPARTSPGPGPQLLLLLLPLFLLLLRDVAGSHRAPAWSALPAAADGLQGDRDLQRHPGDAAATLGPSAQDMVAVHMHRLYEKYSRQGARPGGGNTVRSFRARLEVVDQKAVYFFNLTSMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGRPLPLGPPTRQHLLFRSLSQNTATQGLLRGAMALAPPPRGLWQAKDISPIVKAARRDGELLLSAQLDSEERDPGVPRPSPYAPYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 86 | Phosphorylation | MHRLYEKYSRQGARP HHHHHHHHHHCCCCC | 21082442 | ||
| 87 | Phosphorylation | HRLYEKYSRQGARPG HHHHHHHHHCCCCCC | 21082442 | ||
| 98 | Phosphorylation | ARPGGGNTVRSFRAR CCCCCCCHHHHHHHE | 22817900 | ||
| 101 | Phosphorylation | GGGNTVRSFRARLEV CCCCHHHHHHHEEEE | 24719451 | ||
| 118 | N-linked_Glycosylation | QKAVYFFNLTSMQDS CCEEEEEECCCCCCC | UniProtKB CARBOHYD | ||
| 156 | N-linked_Glycosylation | LCKPRAKNASGRPLP HHCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 176 | Phosphorylation | RQHLLFRSLSQNTAT HHHHHHHHCCCCHHH | 24043423 | ||
| 178 | Phosphorylation | HLLFRSLSQNTATQG HHHHHHCCCCHHHHH | 24043423 | ||
| 181 | Phosphorylation | FRSLSQNTATQGLLR HHHCCCCHHHHHHHH | 24043423 | ||
| 183 | Phosphorylation | SLSQNTATQGLLRGA HCCCCHHHHHHHHHH | 24043423 | ||
| 207 | Phosphorylation | LWQAKDISPIVKAAR CCCCCCCHHHHHHHH | 24719451 | ||
| 281 | N-linked_Glycosylation | PEPRAAPNNSADPRV CCCCCCCCCCCCHHH | UniProtKB CARBOHYD | ||
| 283 | Phosphorylation | PRAAPNNSADPRVRR CCCCCCCCCCHHHHH | - | ||
| 360 | Acetylation | QVLDFDEKTMQKARR HHHCCCHHHHHHHHH | 11790781 | ||
| 396 | Phosphorylation | GWNEWIISPKSFDAY CCCCEEECCCCCCCE | 24719451 | ||
| 469 | N-linked_Glycosylation | VVLKVYPNMSVDTCA EEEEEECCCCCCCCC | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GDF10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GDF10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GDF10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LRP4_HUMAN | LRP4 | physical | 28514442 | |
| MYCB2_HUMAN | MYCBP2 | physical | 28514442 | |
| BANP_HUMAN | BANP | physical | 28514442 | |
| ZN507_HUMAN | ZNF507 | physical | 28514442 | |
| MTHR_HUMAN | MTHFR | physical | 28514442 | |
| FBSP1_HUMAN | FBXO45 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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