GATA5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GATA5_MOUSE
• UniProt AC: P97489
• Protein Name: Transcription factor GATA-5
• Gene Name: Gata5 {ECO:0000312|MGI:MGI:109497}
• Organism: Mus musculus (Mouse).
• Sequence Length: 404
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor required during cardiovascular development (By similarity). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. [PubMed: 9119112 Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity]
• Protein Sequence: MYQSLALAQSPGQGTYADSGAFLHSSGTGSPVFVAPTRMPSMLPYLPSCEPGSQAPALAAHSSWTQAVAADSSAFGSGSPHPPAAHPPGATTFPFAHSPPGSGSGGSAGVRDGGAFQGALLAREQYPTPLGRPMGASYPTTYPAYMSSDVAPSWTSGAFDSSILHGLQARPGGLPGRRTSFVPDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRSGLCCSNCHTATTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNPAKIKGSSGSTANTTASSPTLLNSESSATTLKAESSLASPVCAGPTITSQASSPADESLASSHLEFKFEPEDFAFTSSSMSPQAGLSGVLRQETWCALALA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
180	Phosphorylation	GLPGRRTSFVPDFLE CCCCCCCCCCCHHHH	23.57	21082442
313	Phosphorylation	KIKGSSGSTANTTAS CCCCCCCCCCCCCCC	26.71	-
314	Phosphorylation	IKGSSGSTANTTASS CCCCCCCCCCCCCCC	27.70	-
321	Phosphorylation	TANTTASSPTLLNSE CCCCCCCCCCCCCCC	21.31	27087446
323	Phosphorylation	NTTASSPTLLNSESS CCCCCCCCCCCCCCC	45.91	27087446
330	Phosphorylation	TLLNSESSATTLKAE CCCCCCCCCCCCCCH	26.11	20469934

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GATA5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GATA5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GATA5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN292_MOUSE	Zfp292	physical	20211142
MED16_MOUSE	Med16	physical	20211142
RORB_MOUSE	Rorb	physical	20211142
EP300_HUMAN	EP300	physical	10567378

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.