G137B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: G137B_HUMAN
• UniProt AC: O60478
• Protein Name: Integral membrane protein GPR137B
• Gene Name: GPR137B
• Organism: Homo sapiens (Human).
• Sequence Length: 399
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein .
• Protein Sequence: MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLTCAVLVKTGNWERKVIVSVRVAINDTLFVLCAVSLSICLYKISKMSLANIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQNKSVHSFDYDWYNVSDQADLKNQLGDAGYVLFGVVLFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGGFAPDYYDWGQQTNSFLAQAGTLQDSTLDPDKPSLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	N-linked_Glycosylation	PPWDPARNDSLPPTL CCCCCCCCCCCCCCC	45.38	UniProtKB CARBOHYD
34	Phosphorylation	DSLPPTLTPAVPPYV CCCCCCCCCCCCCCH	16.22	-
40	Phosphorylation	LTPAVPPYVKLGLTV CCCCCCCCHHHCHHH	12.26	-
76	Phosphorylation	RYRHKRLSYQSVFLF HHHHHCCCHHHHHHH	25.76	-
77	Phosphorylation	YRHKRLSYQSVFLFL HHHHCCCHHHHHHHH	14.92	-
79	Phosphorylation	HKRLSYQSVFLFLCL HHCCCHHHHHHHHHH	13.45	-
90	Phosphorylation	FLCLFWASLRTVLFS HHHHHHHHHHHHHHH	14.69	-
145	Phosphorylation	QVIFKAKSKYSPELL HHHHHCHHCCCHHHH	41.51	-
147	Phosphorylation	IFKAKSKYSPELLKY HHHCHHCCCHHHHHH	36.23	-
192	Phosphorylation	WERKVIVSVRVAIND CCEEEEEEEEEEECC	7.96	24719451
263	N-linked_Glycosylation	FILSFSQNKSVHSFD EEEECCCCCCCEECC	37.05	UniProtKB CARBOHYD
275	N-linked_Glycosylation	SFDYDWYNVSDQADL ECCCCCCCCCCHHHH	23.67	UniProtKB CARBOHYD
330	Phosphorylation	TNPGMVPSHGFSPRS CCCCCCCCCCCCCCH	25.49	29507054
334	Phosphorylation	MVPSHGFSPRSYFFD CCCCCCCCCCHHCCC	24.81	29507054
337	Phosphorylation	SHGFSPRSYFFDNPR CCCCCCCHHCCCCCC	29.67	28857561
338	Phosphorylation	HGFSPRSYFFDNPRR CCCCCCHHCCCCCCC	15.00	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of G137B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of G137B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of G137B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CND1_HUMAN	NCAPD2	physical	26186194
SMC2_HUMAN	SMC2	physical	26186194
ZY11B_HUMAN	ZYG11B	physical	26186194
CND2_HUMAN	NCAPH	physical	26186194
DOC2A_HUMAN	DOC2A	physical	26186194
CND3_HUMAN	NCAPG	physical	26186194
DOC2A_HUMAN	DOC2A	physical	28514442
CND1_HUMAN	NCAPD2	physical	28514442
CND2_HUMAN	NCAPH	physical	28514442
CND3_HUMAN	NCAPG	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
SMC2_HUMAN	SMC2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.