| UniProt ID | FXL21_HUMAN | |
|---|---|---|
| UniProt AC | Q9UKT6 | |
| Protein Name | F-box/LRR-repeat protein 21 | |
| Gene Name | FBXL21 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 434 | |
| Subcellular Localization | Cytoplasm, cytosol. Nucleus. Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity).. | |
| Protein Description | Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).. | |
| Protein Sequence | MKRNSLSVENKIVQLSGAAKQPKVGFYSSLNQTHTHTVLLDWGSLPHHVVLQIFQYLPLLDRACASSVCRRWNEVFHISDLWRKFEFELNQSATSSFKSTHPDLIQQIIKKHFAHLQYVSFKVDSSAESAEAACDILSQLVNCSIQTLGLISTAKPSFMNVSESHFVSALTVVFINSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLPKMSSCPHVSSDGILCVADRCQGLRELALNYYILTDELFLALSSETHVNLEHLRIDVVSENPGQIKFHAVKKHSWDALIKHSPRVNVVMHFFLYEEEFETFFKEETPVTHLYFGRSVSKVVLGRVGLNCPRLIELVVCANDLQPLDNELICIAEHCTNLTALGLSKCEVSCSAFIRFVRLCERRLTQLSVMEEVLIPDEDYSLDEIHTEVSKYLGRVWFPDVMPLW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | ENKIVQLSGAAKQPK HHHEEECCCCCCCCC | 14.86 | 29396449 | |
| 84 | Acetylation | HISDLWRKFEFELNQ EHHHHHHHHCEEECC | 37.35 | 12436981 | |
| 98 | Acetylation | QSATSSFKSTHPDLI CHHCCCCHHCCHHHH | 57.29 | 12436991 | |
| 164 | Phosphorylation | SFMNVSESHFVSALT CCCCCCHHHCCEEEE | 18.08 | 22210691 | |
| 168 | Phosphorylation | VSESHFVSALTVVFI CCHHHCCEEEEEEEE | 19.33 | 22210691 | |
| 181 | Phosphorylation | FINSKSLSSIKIEDT EECCCCCCCCEEECC | 36.79 | 24719451 | |
| 416 | Phosphorylation | YSLDEIHTEVSKYLG CCHHHHHHHHHHHHC | 43.68 | - | |
| 419 | Phosphorylation | DEIHTEVSKYLGRVW HHHHHHHHHHHCCCC | 14.89 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FXL21_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FXL21_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FXL21_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CRY1_HUMAN | CRY1 | physical | 24085301 | |
| CRY2_HUMAN | CRY2 | physical | 24085301 | |
| CUL1_HUMAN | CUL1 | physical | 24085301 | |
| SKP1_HUMAN | SKP1 | physical | 24085301 | |
| UBB_HUMAN | UBB | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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