FTSH2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FTSH2_ARATH
• UniProt AC: O80860
• Protein Name: ATP-dependent zinc metalloprotease FTSH 2, chloroplastic
• Gene Name: FTSH2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 695
• Subcellular Localization: Plastid, chloroplast thylakoid membrane ; Single-pass membrane protein ; Stromal side .
• Protein Description: Part of a complex that function as an ATP-dependent zinc metallopeptidase. Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions, but not involved in thermotolerance..
• Protein Sequence: MAASSACLVGNGLSVNTTTKQRLSKHFSGRQTSFSSVIRTSKVNVVKASLDGKKKQEGRRDFLKILLGNAGVGLVASGKANADEQGVSSSRMSYSRFLEYLDKDRVNKVDLYENGTIAIVEAVSPELGNRVERVRVQLPGLSQELLQKLRAKNIDFAAHNAQEDQGSVLFNLIGNLAFPALLIGGLFLLSRRSGGGMGGPGGPGNPLQFGQSKAKFQMEPNTGVTFDDVAGVDEAKQDFMEVVEFLKKPERFTAVGAKIPKGVLLIGPPGTGKTLLAKAIAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFKKAKENAPCIVFVDEIDAVGRQRGTGIGGGNDEREQTLNQLLTEMDGFEGNTGVIVVAATNRADILDSALLRPGRFDRQVSVDVPDVKGRTDILKVHAGNKKFDNDVSLEIIAMRTPGFSGADLANLLNEAAILAGRRARTSISSKEIDDSIDRIVAGMEGTVMTDGKSKSLVAYHEVGHAVCGTLTPGHDAVQKVTLIPRGQARGLTWFIPSDDPTLISKQQLFARIVGGLGGRAAEEIIFGDSEVTTGAVGDLQQITGLARQMVTTFGMSDIGPWSLMDSSAQSDVIMRMMARNSMSEKLAEDIDSAVKKLSDSAYEIALSHIKNNREAMDKLVEVLLEKETIGGDEFRAILSEFTEIPPENRVPSSTTTTPASAPTPAAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAASSACLVGNG ---CCCCCEEEECCC	20.48	22074104
14	Phosphorylation	CLVGNGLSVNTTTKQ EEECCCCCCCCHHHH	18.08	22074104
17	Phosphorylation	GNGLSVNTTTKQRLS CCCCCCCCHHHHHHH	33.42	22074104
32	Phosphorylation	KHFSGRQTSFSSVIR HHCCCCCCCHHHHHH	30.31	29654922
33	Phosphorylation	HFSGRQTSFSSVIRT HCCCCCCCHHHHHHH	18.13	29654922
212	Phosphorylation	NPLQFGQSKAKFQME CCCCCCCCCCCEECC	34.65	25561503
337	Phosphorylation	AVGRQRGTGIGGGND CCCCCCCCCCCCCCH	28.02	25561503
380	Phosphorylation	NRADILDSALLRPGR CCHHHHHHHHCCCCC	19.85	29654922
393	Phosphorylation	GRFDRQVSVDVPDVK CCCCCEEEEECCCCC	12.31	30291188
688	Phosphorylation	STTTTPASAPTPAAV CCCCCCCCCCCCCCC	35.66	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FTSH2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FTSH2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FTSH2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FTSH5_ARATH	VAR1	physical	14630971
FTSH2_ARATH	VAR2	physical	24964212
FTSH4_ARATH	ftsh4	physical	24964212

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.