FTCD_HUMAN - dbPTM
FTCD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FTCD_HUMAN
UniProt AC O95954
Protein Name Formimidoyltransferase-cyclodeaminase
Gene Name FTCD
Organism Homo sapiens (Human).
Sequence Length 541
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Golgi apparatus. More abundantly located around the mother centriole.
Protein Description Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi..
Protein Sequence MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDLQVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
100PhosphorylationFIPVRGVSVDECVLC
CCCCCCCCHHHHHHH		27.0328857561
124PhosphorylationEELDVPVYLYGEAAR
HHCCCCEEEEEHHHC		6.53-
146PhosphorylationPAIRAGEYEALPKKL
CCHHHCCCCCCCHHH		12.9421253578
225PhosphorylationKVQGIGWYLDEKNLA
CCEECCEEECHHCHH		10.08-
250PhosphorylationVTALHTVYEETCREA
HHHHHHHHHHHHHHH		14.81-
305PhosphorylationQRIRLVVSRLGLDSL
HHHHHHHHHCCCCCC		17.8224719451
316PhosphorylationLDSLCPFSPKERIIE
CCCCCCCCCHHHHHH		21.8728857561
324PhosphorylationPKERIIEYLVPERGP
CHHHHHHHHCCCCCC		11.5521253578
339PhosphorylationERGLGSKSLRAFVGE
CCCCCCHHHHHHHHH		25.4525954137
351PhosphorylationVGEVGARSAAPGGGS
HHHHHHCCCCCCCHH		28.4025954137
358PhosphorylationSAAPGGGSVAAAAAA
CCCCCCHHHHHHHHH		16.32-
378PhosphorylationGSMVGLMTYGRRQFQ
HHHHHHHHHCHHHHH		28.0625954137
381MethylationVGLMTYGRRQFQSLD
HHHHHHCHHHHHCHH		20.86-
386PhosphorylationYGRRQFQSLDTTMRR
HCHHHHHCHHHHHHH		29.5128857561
389PhosphorylationRQFQSLDTTMRRLIP
HHHHCHHHHHHHHCC		27.9924275569
390PhosphorylationQFQSLDTTMRRLIPP
HHHCHHHHHHHHCCH		14.3524275569
399MethylationRRLIPPFREASAKLT
HHHCCHHHHHHHHHH		44.33-
402PhosphorylationIPPFREASAKLTTLV
CCHHHHHHHHHHHHH		22.60-
424MethylationTAYLEAMRLPKNTPE
HHHHHHHCCCCCCHH		55.69-
436DimethylationTPEEKDRRTAALQEG
CHHHHHHHHHHHHHH		38.56-
436MethylationTPEEKDRRTAALQEG
CHHHHHHHHHHHHHH		38.56-
445DimethylationAALQEGLRRAVSVPL
HHHHHHHHHHHCCCH		35.06-
445MethylationAALQEGLRRAVSVPL
HHHHHHHHHHHCCCH		35.06-
449PhosphorylationEGLRRAVSVPLTLAE
HHHHHHHCCCHHHHH		19.6224275569
519PhosphorylationDQIHHRVSSLLQEAK
HHHHHHHHHHHHHHH		18.4121082442
520PhosphorylationQIHHRVSSLLQEAKT
HHHHHHHHHHHHHHH		30.1828857561
541 (in isoform 2)Phosphorylation-60.3430631047
544 (in isoform 2)Phosphorylation-30631047
549 (in isoform 2)Phosphorylation-24275569
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FTCD_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FTCD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FTCD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GRB14_HUMANGRB14physical
11278563
MED4_HUMANMED4physical
25416956
KASH5_HUMANCCDC155physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
229100Glutamate formiminotransferase deficiency (FIGLU-URIA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00116Tetrahydrofolic acid
Regulatory Network of FTCD_HUMAN

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Related Literatures of Post-Translational Modification

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