FGFP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGFP1_HUMAN
• UniProt AC: Q14512
• Protein Name: Fibroblast growth factor-binding protein 1
• Gene Name: FGFBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 234
• Subcellular Localization: Secreted, extracellular space . Cell membrane ; Peripheral membrane protein . Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.
• Protein Description: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth..
• Protein Sequence: MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	O-linked_Glycosylation	GLHSKVVSEQKDTLG CCCHHHHCCCCCCCC	36.98	55835739
37	Phosphorylation	GLHSKVVSEQKDTLG CCCHHHHCCCCCCCC	36.98	24505115
46	O-linked_Glycosylation	QKDTLGNTQIKQKSR CCCCCCCCCCEECCC	29.85	55835743
57	Acetylation	QKSRPGNKGKFVTKD ECCCCCCCCCCCCCC	70.19	7696031
73	Phosphorylation	ANCRWAATEQEEGIS CCCEEEEECCCCCEE	30.38	27732954
73	O-linked_Glycosylation	ANCRWAATEQEEGIS CCCEEEEECCCCCEE	30.38	55833703
80	Phosphorylation	TEQEEGISLKVECTQ ECCCCCEEEEEEEEE	32.75	25159151
169	O-linked_Glycosylation	RKEKTEMSPREHIKG CHHCCCCCCCHHHCC	17.99	UniProtKB CARBOHYD
179	O-linked_Glycosylation	EHIKGKETTPSSLAV HHHCCCCCCHHHHHH	47.71	55827595
180	O-linked_Glycosylation	HIKGKETTPSSLAVT HHCCCCCCHHHHHHH	23.43	55827601
180	Phosphorylation	HIKGKETTPSSLAVT HHCCCCCCHHHHHHH	23.43	23532336
182	O-linked_Glycosylation	KGKETTPSSLAVTQT CCCCCCHHHHHHHHH	35.57	55827605
187	O-linked_Glycosylation	TPSSLAVTQTMATKA CHHHHHHHHHHCCCC	16.83	55827609
189	O-linked_Glycosylation	SSLAVTQTMATKAPE HHHHHHHHHCCCCCH	10.21	55827615
192	O-linked_Glycosylation	AVTQTMATKAPECVE HHHHHHCCCCCHHHC	19.54	55827621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGFP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGFP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGFP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FGFP1_HUMAN	FGFBP1	physical	11291074
PGBM_HUMAN	HSPG2	physical	11148217
FGF1_HUMAN	FGF1	physical	11509569
FGF2_HUMAN	FGF2	physical	11509569

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.