FANCC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FANCC_MOUSE
• UniProt AC: P50652
• Protein Name: Fanconi anemia group C protein homolog
• Gene Name: Fancc
• Organism: Mus musculus (Mouse).
• Sequence Length: 591
• Subcellular Localization: Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
• Protein Description: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity)..
• Protein Sequence: MAQESADLASDCQSWLQKLSAWEQASSEETQKDTCLHLSGFQEFLRQMYEILKEMDSDAILERFPTIGQLLAKACWNPLILAYDESQKIVIWCLCCLMNKEPRTSAESGLNSWIRGLLSHVLSAFRFDMKEVCLFTKSLGYESIDYYPSLLKNMVLSLVSELRESHLNGLSTQSRMAPERMMSLSEVCVPLVTLPDMEPLVEALLTYHGHEPQEVLAPEFFEAVNEAFLSEKIVLPTSSVVSLWFRHLPSLEKATLHLFEKLFSSKIICLRRMECCIRESFLPQAACQPAIFRIVDEMFRFVLLETDGAPEVLAALQVFTSCLVEALKKENKQLTFALRTYFPYGAPCLAAALSQHPEAIPQGHRLQPLLHISQLLREAVEDCTRGSPRNPFESWFLFVHFGGWVDLAVAELLLREEAEPPAGLLWLLVFYYSPQDGSQQREQSMVELKVLINRLLMLLRSGPLSATDLQEAAESPSGDPRPPVCGQLVRRLLLSLLLWTPEGHAIVWEAVTHGPTFEITGPGCCPRIWRSTRPQHRPRAHLCCTEMAHTDAVIHEIIGFLDQTLYRSQHLCVEASRKLARDLLKELQAQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAQESADLASDC ---CCHHHHHHHHHH	18.27	22067460
20	Phosphorylation	QSWLQKLSAWEQASS HHHHHHHHHHHHCCC	38.07	25521595
26	Phosphorylation	LSAWEQASSEETQKD HHHHHHCCCHHHHHH	37.67	25521595
27	Phosphorylation	SAWEQASSEETQKDT HHHHHCCCHHHHHHH	42.33	25521595
83	Phosphorylation	WNPLILAYDESQKIV CCCHHHCCCHHHHHH	19.46	17203969
84	Phosphorylation	NPLILAYDESQKIVI CCHHHCCCHHHHHHH	43.39	17203969
86	Phosphorylation	LILAYDESQKIVIWC HHHCCCHHHHHHHHH	33.60	17203969
141	Phosphorylation	LFTKSLGYESIDYYP HHCCCCCCCCHHCCH	16.28	25521595
143	Phosphorylation	TKSLGYESIDYYPSL CCCCCCCCHHCCHHH	16.57	25521595
147	Phosphorylation	GYESIDYYPSLLKNM CCCCHHCCHHHHHHH	5.21	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FANCC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FANCC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FANCC_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSTP1_MOUSE	Gstp1	physical	11433346
NCPR_MOUSE	Por	physical	9787138
FP100_HUMAN	C17orf70	physical	20360068
FANCB_HUMAN	FANCB	physical	20360068
FANCE_HUMAN	FANCE	physical	20360068
LASP1_HUMAN	LASP1	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.