UniProt ID | FAIM3_HUMAN | |
---|---|---|
UniProt AC | O60667 | |
Protein Name | Fas apoptotic inhibitory molecule 3 {ECO:0000305} | |
Gene Name | FCMR {ECO:0000312|HGNC:HGNC:14315} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 390 | |
Subcellular Localization |
Isoform 1: Membrane Single-pass membrane protein . Isoform 3: Secreted . Detected in the serum. |
|
Protein Description | May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.. | |
Protein Sequence | MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
32 | Phosphorylation | VEGELGGSVTIKCPL EEEECCCCEEEECCC | 17.81 | - | |
92 | Phosphorylation | NLFLVEVTQLTESDS CEEEEEEEECCCCCC | 12.35 | - | |
224 | O-linked_Glycosylation | EGLLKPQTPSYNHHT HHHCCCCCCCCCHHH | 23.80 | OGP | |
298 | Phosphorylation | VRMRALESSQRPRGS HHHHHHHHCCCCCCC | 32.40 | 24719451 | |
305 | Phosphorylation | SSQRPRGSPRPRSQN HCCCCCCCCCCCCCC | 21.00 | 24719451 | |
310 | Phosphorylation | RGSPRPRSQNNIYSA CCCCCCCCCCCHHHC | 39.69 | 30108239 | |
315 | Phosphorylation | PRSQNNIYSACPRRA CCCCCCHHHCCCCHH | 7.73 | 27155012 | |
316 | Phosphorylation | RSQNNIYSACPRRAR CCCCCHHHCCCCHHC | 21.43 | 30108239 | |
366 | Phosphorylation | SLKTSCEYVSLYHQP CCCCCCEEEECCCCC | 10.32 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FAIM3_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FAIM3_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FAIM3_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ZNHI3_HUMAN | ZNHIT3 | physical | 20211142 | |
ANKR2_HUMAN | ANKRD2 | physical | 20211142 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...