FAIM3_HUMAN - dbPTM
FAIM3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FAIM3_HUMAN
UniProt AC O60667
Protein Name Fas apoptotic inhibitory molecule 3 {ECO:0000305}
Gene Name FCMR {ECO:0000312|HGNC:HGNC:14315}
Organism Homo sapiens (Human).
Sequence Length 390
Subcellular Localization Isoform 1: Membrane
Single-pass membrane protein .
Isoform 3: Secreted . Detected in the serum.
Protein Description May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation..
Protein Sequence MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
32PhosphorylationVEGELGGSVTIKCPL
EEEECCCCEEEECCC
17.81-
92PhosphorylationNLFLVEVTQLTESDS
CEEEEEEEECCCCCC
12.35-
224O-linked_GlycosylationEGLLKPQTPSYNHHT
HHHCCCCCCCCCHHH
23.80OGP
298PhosphorylationVRMRALESSQRPRGS
HHHHHHHHCCCCCCC
32.4024719451
305PhosphorylationSSQRPRGSPRPRSQN
HCCCCCCCCCCCCCC
21.0024719451
310PhosphorylationRGSPRPRSQNNIYSA
CCCCCCCCCCCHHHC
39.6930108239
315PhosphorylationPRSQNNIYSACPRRA
CCCCCCHHHCCCCHH
7.7327155012
316PhosphorylationRSQNNIYSACPRRAR
CCCCCHHHCCCCHHC
21.4330108239
366PhosphorylationSLKTSCEYVSLYHQP
CCCCCCEEEECCCCC
10.32-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FAIM3_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FAIM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FAIM3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZNHI3_HUMANZNHIT3physical
20211142
ANKR2_HUMANANKRD2physical
20211142

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FAIM3_HUMAN

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Related Literatures of Post-Translational Modification

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