F261_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F261_HUMAN
• UniProt AC: P16118
• Protein Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
• Gene Name: PFKFB1
• Organism: Homo sapiens (Human).
• Sequence Length: 471
• Protein Description: Synthesis and degradation of fructose 2,6-bisphosphate..
• Protein Sequence: MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSPEMGELT ------CCHHHHHCC	29.57	-
2	Phosphorylation	------MSPEMGELT ------CCHHHHHCC	29.57	20166139
9	Phosphorylation	SPEMGELTQTRLQKI CHHHHHCCCHHHHHH	24.48	29083192
11	Phosphorylation	EMGELTQTRLQKIWI HHHHCCCHHHHHHCC	28.28	29083192
21	Phosphorylation	QKIWIPHSSGSSRLQ HHHCCCCCCCCHHHH	30.92	22210691
22	Phosphorylation	KIWIPHSSGSSRLQR HHCCCCCCCCHHHHH	39.39	22210691
24	Phosphorylation	WIPHSSGSSRLQRRR CCCCCCCCHHHHHHC	17.77	24275569
33	Phosphorylation	RLQRRRGSSIPQFTN HHHHHCCCCCCCCCC	24.23	24275569
34	Phosphorylation	LQRRRGSSIPQFTNS HHHHCCCCCCCCCCC	40.90	28348404
39	Phosphorylation	GSSIPQFTNSPTMVI CCCCCCCCCCCCEEE	29.55	24275569
133	Phosphorylation	HVAVFDATNTTRERR CEEEEECCCCHHHHH	34.64	26437602
141	Phosphorylation	NTTRERRSLILQFAK CCHHHHHHHHHHHHH	26.44	-
200	Phosphorylation	FLKRIECYEVNYQPL HHHHCCEEECCCCCC	15.32	-
204	Phosphorylation	IECYEVNYQPLDEEL CCEEECCCCCCCHHH	19.38	-
227	Phosphorylation	IFDVGTRYMVNRVQD EEECCHHHHHHHHHH	12.78	25884760
242	Phosphorylation	HIQSRTVYYLMNIHV HHHHCCEEEEEECCC	7.11	-
243	Phosphorylation	IQSRTVYYLMNIHVT HHHCCEEEEEECCCC	8.64	25884760
262	Phosphorylation	YLCRHGESELNIRGR EEECCCCCEEEECCE	52.56	24719451
277	Phosphorylation	IGGDSGLSVRGKQYA ECCCCCCCCCCHHHH	17.19	24719451
297	Phosphorylation	FIQSQGISSLKVWTS HHHHCCCCHHHHHHH	36.12	24719451
299	Ubiquitination	QSQGISSLKVWTSHM HHCCCCHHHHHHHHH	4.07	-
364	Ubiquitination	KYRYRYPKGESYEDL CCCCCCCCCCCHHHH	67.39	-
438	Phosphorylation	GCKVESIYLNVEAVN CCEEEEEEEEEEEHH	11.08	19651622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
33	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F261_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F261_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
F261_HUMAN	PFKFB1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.