F200A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F200A_HUMAN
• UniProt AC: Q8TCP9
• Protein Name: Protein FAM200A
• Gene Name: FAM200A
• Organism: Homo sapiens (Human).
• Sequence Length: 573
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MTPESRDTTDLSPGGTQEMEGIVIVKVEEEDEEDHFQKERNKVESSPQVLSRSTTMNERALLSSYLVAYRVAKEKMAHTAAEKIILPACMDMVRTIFDDKSADKLRTIPLSDNTISRRICTIAKHLEAMLITRLQSGIDFAIQLDESTDIASCPTLLVYVRYVWQDDFVEDLLCCLNLNSHITGLDLFTELENCLLGQYKLNWKHCKGISSDGTANMTGKHSRLTEKLLEATHNNAVWNHCFIHREALVSKEISPSLMDVLKNAVKTVNFIKGSSLNSRLLEIFCSEIGVNHTHLLFHTEVRWLSQGKVLSRVYELRNEIYIFLVEKQSHLANIFEDDIWVTKLAYLSDIFGILNELSLKMQGKNNDIFQYLEHILGFQKTLLLWQARLKSNRPSYYMFPTLLQHIEENIINEDCLKEIKLEILLHLTSLSQTFNYYFPEEKFESLKENIWMKDPFAFQNPESIIELNLEPEEENELLQLSSSFTLKNYYKILSLSAFWIKIKDDFPLLSRKSILLLLPFTTTYLCELGFSILTRLKTKKRNRLNSAPDMRVALSSCVPDWKELMNRQAHPSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTPESRDTT ------CCCCCCCCC	35.45	-
5	Phosphorylation	---MTPESRDTTDLS ---CCCCCCCCCCCC	36.34	-
16	Phosphorylation	TDLSPGGTQEMEGIV CCCCCCCCCEEEEEE	27.54	-
42	Ubiquitination	HFQKERNKVESSPQV HHHHHHHHHCCCHHH	54.31	-
45	Phosphorylation	KERNKVESSPQVLSR HHHHHHCCCHHHHCC	50.75	29255136
46	Phosphorylation	ERNKVESSPQVLSRS HHHHHCCCHHHHCCC	13.07	29255136
53	Phosphorylation	SPQVLSRSTTMNERA CHHHHCCCCCCCHHH	25.50	-
54	Phosphorylation	PQVLSRSTTMNERAL HHHHCCCCCCCHHHH	29.02	29759185
55	Phosphorylation	QVLSRSTTMNERALL HHHCCCCCCCHHHHH	21.17	-
63	Phosphorylation	MNERALLSSYLVAYR CCHHHHHHHHHHHHH	20.14	30622161
64	Phosphorylation	NERALLSSYLVAYRV CHHHHHHHHHHHHHH	23.58	30622161
65	Phosphorylation	ERALLSSYLVAYRVA HHHHHHHHHHHHHHH	11.21	30622161
69	Phosphorylation	LSSYLVAYRVAKEKM HHHHHHHHHHHHHHH	9.72	30622161
83	Ubiquitination	MAHTAAEKIILPACM HCCHHHHHCHHHHHH	30.25	29967540
100	Ubiquitination	VRTIFDDKSADKLRT HHHHCCCCCCCCCCC	49.76	-
104	Ubiquitination	FDDKSADKLRTIPLS CCCCCCCCCCCCCCC	39.32	-
207	Ubiquitination	KLNWKHCKGISSDGT CCCCCCCCCCCCCCC	60.02	-
220	Ubiquitination	GTANMTGKHSRLTEK CCCCCCCCCHHHHHH	29.28	29967540
227	Ubiquitination	KHSRLTEKLLEATHN CCHHHHHHHHHHHCC	53.81	-
251	Ubiquitination	HREALVSKEISPSLM CHHHHHCCCCCHHHH	52.14	29967540
272	Ubiquitination	VKTVNFIKGSSLNSR HHHHHHHCCCCHHHH	48.91	27667366
391	Acetylation	LWQARLKSNRPSYYM HHHHHHHHCCCCHHH	42.54	19413330
428	Phosphorylation	LEILLHLTSLSQTFN HHHHHHHHCHHHHHC	19.51	26074081
429	Phosphorylation	EILLHLTSLSQTFNY HHHHHHHCHHHHHCH	32.17	26074081
431	Phosphorylation	LLHLTSLSQTFNYYF HHHHHCHHHHHCHHC	27.26	26074081
433	Phosphorylation	HLTSLSQTFNYYFPE HHHCHHHHHCHHCCH	15.52	26074081
436	Phosphorylation	SLSQTFNYYFPEEKF CHHHHHCHHCCHHHH	11.42	26074081
437	Phosphorylation	LSQTFNYYFPEEKFE HHHHHCHHCCHHHHH	17.48	26074081
494	Phosphorylation	KNYYKILSLSAFWIK HHHHHHHEEEEEEEE	24.61	-
496	Phosphorylation	YYKILSLSAFWIKIK HHHHHEEEEEEEEEC	20.31	-
510	Phosphorylation	KDDFPLLSRKSILLL CCCCCCCCCCHHEHH	45.40	-
531	Phosphorylation	YLCELGFSILTRLKT HHHHHCHHHHHHHHC	18.19	24719451
546	Phosphorylation	KKRNRLNSAPDMRVA CCCCCCCCCCCHHHH	45.85	29255136
555	Phosphorylation	PDMRVALSSCVPDWK CCHHHHHHHHCCCHH	16.38	22210691
556	Phosphorylation	DMRVALSSCVPDWKE CHHHHHHHHCCCHHH	21.71	22210691
562	Ubiquitination	SSCVPDWKELMNRQA HHHCCCHHHHHHHCC	48.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F200A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F200A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F200A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
F200A_HUMAN	FAM200A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.