ERF3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERF3_SCHPO
• UniProt AC: O74718
• Protein Name: Eukaryotic peptide chain release factor GTP-binding subunit
• Gene Name: sup35
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 662
• Subcellular Localization: Cytoplasm .
• Protein Description: Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides..
• Protein Sequence: MASNQPNNGEQDEQLAKQTSKLSMSAKAPTFTPKAAPFIPSFQRPGFVPVNNIAGGYPYAQYTGQGQNSNSPHPTKSYQQYYQKPTGNTVDEDKSRVPDFSKKKSFVPPKPAIPKGKVLSLGGNTSAPKSTKPISISLGGTKAPTTTKPAAPAAQSKTETPAPKVTSESTKKETAAPPPQETPTKSADAELAKTPSAPAAALKKAAEAAEPATVTEDATDLQNEVDQELLKDMYGKEHVNIVFIGHVDAGKSTLGGNILFLTGMVDKRTMEKIEREAKEAGKESWYLSWALDSTSEEREKGKTVEVGRAYFETEHRRFSLLDAPGHKGYVTNMINGASQADIGVLVISARRGEFEAGFERGGQTREHAVLARTQGINHLVVVINKMDEPSVQWSEERYKECVDKLSMFLRRVAGYNSKTDVKYMPVSAYTGQNVKDRVDSSVCPWYQGPSLLEYLDSMTHLERKVNAPFIMPIASKYKDLGTILEGKIEAGSIKKNSNVLVMPINQTLEVTAIYDEADEEISSSICGDQVRLRVRGDDSDVQTGYVLTSTKNPVHATTRFIAQIAILELPSILTTGYSCVMHIHTAVEEVSFAKLLHKLDKTNRKSKKPPMFATKGMKIIAELETQTPVCMERFEDYQYMGRFTLRDQGTTVAVGKVVKILD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	NIAGGYPYAQYTGQG CCCCCCCCCEECCCC	9.61	27738172
71	Phosphorylation	GQGQNSNSPHPTKSY CCCCCCCCCCCCCCH	25.14	21712547
77	Phosphorylation	NSPHPTKSYQQYYQK CCCCCCCCHHHHHCC	30.56	24763107
120	Phosphorylation	IPKGKVLSLGGNTSA CCCCCEEEECCCCCC	28.14	28889911
130	Phosphorylation	GNTSAPKSTKPISIS CCCCCCCCCCCEEEE	40.37	25720772
174	Phosphorylation	SESTKKETAAPPPQE CCCCCCCCCCCCCCC	36.68	29996109
182	Phosphorylation	AAPPPQETPTKSADA CCCCCCCCCCCCCCH	30.89	28889911
184	Phosphorylation	PPPQETPTKSADAEL CCCCCCCCCCCCHHH	45.08	25720772
194	Phosphorylation	ADAELAKTPSAPAAA CCHHHHCCCCCHHHH	19.50	21712547
196	Phosphorylation	AELAKTPSAPAAALK HHHHCCCCCHHHHHH	52.71	24763107
319	Phosphorylation	ETEHRRFSLLDAPGH ECCCCCEEEECCCCC	26.64	25720772
539	Phosphorylation	LRVRGDDSDVQTGYV EEEECCCCCCCCCEE	44.41	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERF3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERF3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERF3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERF1_SCHPO	sup45	physical	9701287
DOM34_SCHPO	dom34	physical	9701287
DOM34_SCHPO	dom34	physical	10376874
ERF3_SCHPO	sup35	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182 AND SER-539, ANDMASS SPECTROMETRY.
PubMed: 18257517