ERF1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERF1_SCHPO
• UniProt AC: P79063
• Protein Name: Eukaryotic peptide chain release factor subunit 1
• Gene Name: sup45
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 433
• Subcellular Localization: Cytoplasm.
• Protein Description: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA..
• Protein Sequence: MSETAEKAIEIWKIRRLVKQLINCHGNGTSMITLIIPPGEQISRYSNMLAEEYGTASNIKSRVNRLSVLSAITSTRERLKLYNKVPDNGLVIYCGEVIMEGNKTRKLNIDFEPFKPINTSQYLCDNKFHTEALAELLESDQRFGFIVMDGHQTLYGVVSGSAREVLQRFTVDLPKKHGRGGQSALRFARLRDEKRHNYVRKVAEGAVQHFITDDKPNVAGIVLAGSADFKTELGQSDLFDQRLQSRIIKTVDVSYGGDAGFNQAIELAADTLSNVKYVQEKKLIQRFFDEISLDSGKYCFGVVDTMNALQEGAVETLLCFADLDMIRYEFKNSEGNPVITYMTKEQEEKDSTNSFLLDKDTGAEMELVSSMLLSEWLAEHYKDYGANLEFVSDRSQEGMQFVKGFGGIGAVMRYQLDLSMLDPESDEFYSDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	VNRLSVLSAITSTRE HHHHHHHHHHHCHHH	18.57	25720772
182	Methylation	KKHGRGGQSALRFAR HHHCCCHHHHHHHHH	28.49	-
351	Phosphorylation	KEQEEKDSTNSFLLD HHHHCCCCCCCCEEC	40.32	21712547
354	Phosphorylation	EEKDSTNSFLLDKDT HCCCCCCCCEECCCC	19.84	24763107
425	Phosphorylation	LSMLDPESDEFYSDS HHHCCCCCCCCCCCC	48.07	28889911
429	Phosphorylation	DPESDEFYSDSD--- CCCCCCCCCCCC---	14.99	27738172
430	Phosphorylation	PESDEFYSDSD---- CCCCCCCCCCC----	35.64	24763107
432	Phosphorylation	SDEFYSDSD------ CCCCCCCCC------	39.00	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERF1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERF1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERF1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JMJ1_SCHPO	jmj1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, AND MASSSPECTROMETRY.
PubMed: 18257517