ERCC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERCC1_MOUSE
• UniProt AC: P07903
• Protein Name: DNA excision repair protein ERCC-1
• Gene Name: Ercc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 298
• Subcellular Localization: Nucleus.
• Protein Description: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity)..
• Protein Sequence: MDPGKDEESRPQPSGPPTRRKFVIPLEEEEVPCAGVKPLFRSSRNPTIPATSAHVAPQTYAEYAITQPPGGAGATVPTGSEPAAGENPSQTLKTGAKSNSIIVSPRQRGNPVLKFVRNVPWEFGEVIPDYVLGQSTCALFLSLRYHNLHPDYIHERLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLVLAWSAEEAGRYLETYKAYEQKPADLLMEKLEQNFLSRATECLTTVKSVNKTDSQTLLATFGSLEQLFTASREDLALCPGLGPQKARRLFEVLHEPFLKVPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPGKDEE -------CCCCCCCC	14.66	-
37	Ubiquitination	EVPCAGVKPLFRSSR CCCCCCCCCCEECCC	34.78	-
247	Ubiquitination	TTVKSVNKTDSQTLL HHHHCCCCCCHHHHH	52.10	-
248	Phosphorylation	TVKSVNKTDSQTLLA HHHCCCCCCHHHHHH	35.36	26643407
250	Phosphorylation	KSVNKTDSQTLLATF HCCCCCCHHHHHHHH	30.23	26643407
252	Phosphorylation	VNKTDSQTLLATFGS CCCCCHHHHHHHHCC	27.91	26643407
256	Phosphorylation	DSQTLLATFGSLEQL CHHHHHHHHCCHHHH	28.62	26643407
259	Phosphorylation	TLLATFGSLEQLFTA HHHHHHCCHHHHHHC	25.25	21454597
265	Phosphorylation	GSLEQLFTASREDLA CCHHHHHHCCHHHHC	32.11	21454597
267	Phosphorylation	LEQLFTASREDLALC HHHHHHCCHHHHCCC	32.90	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERCC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
48	K	ubiquitylation	Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages.	-
63	K	ubiquitylation	Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERCC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SLX4_MOUSE	Slx4	physical	25538220
UBP45_MOUSE	Usp45	physical	25538220

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.