EIF3H_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3H_DROME
• UniProt AC: Q9U9Q4
• Protein Name: Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007}
• Gene Name: eIF3h {ECO:0000255|HAMAP-Rule:MF_03007}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 338
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation..
• Protein Sequence: MANRANRHAARTEDSDNTINYVQCDGLAVMKMVKHCHEESSNMDLAQGALLGLVVDKCLEITNCFPFPKSGDETMDEEMYQLTVMRRLRRVNVDHLHVGWYQSSDVGNSLSMALLESQYHYQTSIEESVVVVYDTQKSSRGFLCLKAYRLTPQAIQMYKDGDFTPEAFRTLKVGYENLFAEIPIVIKNSPLTNIMMSELNELLPEDKGHNFLDLGTATVLENQMRSLIERVDELYQEAVRYNKYQQVVFKQDTEKHRALAKLAAENAVRTSKGEPTVPEEEVIKQFRPMTAPNRLTATITSGQINTHAQHIAQFCSQSLAKLFITESLQIAKEAKETK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
146	Acetylation	SRGFLCLKAYRLTPQ CCCEEEEEEEEECHH	42.23	21791702
243	Acetylation	QEAVRYNKYQQVVFK HHHHHCCCCCEEEEE	35.19	21791702
250	Acetylation	KYQQVVFKQDTEKHR CCCEEEEECCHHHHH	35.34	21791702
261	Acetylation	EKHRALAKLAAENAV HHHHHHHHHHHHHHH	39.24	21791702
261	Ubiquitination	EKHRALAKLAAENAV HHHHHHHHHHHHHHH	39.24	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3H_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3H_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3H_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3L_DROME	CG5642	physical	22036573
EIF3M_DROME	Tango7	physical	22036573
EIF3E_DROME	Int6	physical	22036573
EI3F1_DROME	CG9769	physical	22036573
EIF3C_DROME	eIF3-S8	physical	22036573
EIF3K_DROME	CG10306	physical	22036573
EIF3B_DROME	eIF3-S9	physical	22036573
EI3GA_DROME	CG8636	physical	22036573
EIF3A_DROME	eIF3-S10	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.